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10.1002/jmv.26443

http://scihub22266oqcxt.onion/10.1002/jmv.26443
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32813283!7461548!32813283
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suck abstract from ncbi


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pmid32813283      J+Med+Virol 2021 ; 93 (2): 1171-1174
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  • Effectiveness of remdesivir for the treatment of hospitalized COVID-19 persons: A network meta-analysis #MMPMID32813283
  • Jiang Y; Chen D; Cai D; Yi Y; Jiang S
  • J Med Virol 2021[Feb]; 93 (2): 1171-1174 PMID32813283show ga
  • Several randomized clinical trials (RCTs) that investigated the effectiveness of remdesivir for the treatment of coronavirus disease-2019 (COVID-19) have generated inconsistent evidence. The present study aimed to synthesize available RCT evidence using network meta-analyses (NMAs). Both blinded and open-label RCTs in PubMed database from inception to 7 June 2020 that contained "remdesivir", "Covid-19", and "trial" in the abstracts conducted on hospitalized COVID-19 persons were identified and screened. The studies must have at least one remdesivir arm and evaluated one of the pre-specified outcomes. The outcomes were clinical improvement between days 10 to 15 after randomization and clinical recovery during the follow-up period. The identified literature was supplemented with relatively recent studies that were known to the researchers if not already included. Frequentist NMAs with random effects were conducted. Both 10-day and 5-day remdesivir regimens were associated with higher odds of clinical improvement (odds ratio [OR] of 10-day regimen: 1.35, 95% confidence interval [CI], 1.09-1.67); OR of 5-day regimen: 1.81, 95% CI, 1.32-2.45, and higher probabilities of clinical recovery (relative risk [RR] of 10-day regimen: 1.24, 95% CI, 1.07-1.43; RR of 5-day regimen: 1.47, 95% CI, 1.16-1.87 compared with placebo. Remdesivir may have clinical benefits among hospitalized COVID-19 persons.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Network Meta-Analysis[MESH]
  • |Adenosine Monophosphate/*analogs & derivatives/therapeutic use[MESH]
  • |Alanine/*analogs & derivatives/therapeutic use[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]


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