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10.1111/cei.13506 http://scihub22266oqcxt.onion/10.1111/cei.13506 32812215!7670149!32812215     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Exp+Immunol 2020 ; 202 (3): 263-272 Nephropedia Template TP {{tp|p=32812215|t=2020. Characterization of circulating immune cells in acute Kawasaki disease suggests exposure to different antigens |pdf=|usr=}}{{32812215}} gab.com Text Characterization of circulating immune cells in acute Kawasaki disease suggests exposure to different antigens JO: Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32812215 #FOAvip Kawasaki disease (KD) is an acute pediatric vasculitis of unknown etiology that can cause coronary artery aneurysms, and is the leading cause of acquired heart disease in children. We studied aspects of the innate and adaptive immune response in 17 acute KD children prior to treatment with intravenous immunoglobulin. Distinct patterns within the innate immune response correlated with specific clinical features. Proinflammatory myeloid dendritic cells (mDC) were abundant in four of 17 (23.5%) subjects who were older and manifested severe inflammation with clinical myocarditis and elevated hepatobiliary enzyme levels. Of the nine subjects with low levels of anti-inflammatory, tolerogenic mDC, six had enlarged cervical lymph nodes at diagnosis. In contrast, the adaptive immune repertoire varied greatly with no discernible patterns or associations with clinical features. Two subjects with aneurysms had numerous circulating CD8(+) T cells. Ten subjects showed low CD4(+) T cell numbers and seven subjects had CD4(+) T cells in the normal range. CD4(+) T cells expressed interleukin-7 receptor (IL-7R), suggesting repeated antigenic stimulation. Thymic-derived regulatory T cells (nT(reg) ) and peripherally induced regulatory T cells (iT(reg) ) were also enumerated, with the majority having the nT(reg) phenotype. Natural killer (NK) and NK T cell numbers were similar across all subjects. Taken together, the results of the immune monitoring suggest that KD may have multiple triggers that stimulate different arms of the innate and adaptive compartment in KD patients. Thus, it is possible that diverse antigens may participate in the pathogenesis of KD. Twit Text FOAVip Characterization of circulating immune cells in acute Kawasaki disease suggests exposure to different antigens ????Clin Exp Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32812215 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32812215 #FOAvip English Wikipedia <ref>{{Cite pmid|32812215}}</ref> Characterization of circulating immune cells in acute Kawasaki disease suggests exposure to different antigens #MMPMID32812215 Burns JC; Hsieh LE; Kumar J; Behnamfar N; Shimizu C; Sivilay N; Tremoulet AH; Franco A Clin Exp Immunol 2020[Dec]; 202 (3): 263-272 PMID32812215show ga Kawasaki disease (KD) is an acute pediatric vasculitis of unknown etiology that can cause coronary artery aneurysms, and is the leading cause of acquired heart disease in children. We studied aspects of the innate and adaptive immune response in 17 acute KD children prior to treatment with intravenous immunoglobulin. Distinct patterns within the innate immune response correlated with specific clinical features. Proinflammatory myeloid dendritic cells (mDC) were abundant in four of 17 (23.5%) subjects who were older and manifested severe inflammation with clinical myocarditis and elevated hepatobiliary enzyme levels. Of the nine subjects with low levels of anti-inflammatory, tolerogenic mDC, six had enlarged cervical lymph nodes at diagnosis. In contrast, the adaptive immune repertoire varied greatly with no discernible patterns or associations with clinical features. Two subjects with aneurysms had numerous circulating CD8(+) T cells. Ten subjects showed low CD4(+) T cell numbers and seven subjects had CD4(+) T cells in the normal range. CD4(+) T cells expressed interleukin-7 receptor (IL-7R), suggesting repeated antigenic stimulation. Thymic-derived regulatory T cells (nT(reg) ) and peripherally induced regulatory T cells (iT(reg) ) were also enumerated, with the majority having the nT(reg) phenotype. Natural killer (NK) and NK T cell numbers were similar across all subjects. Taken together, the results of the immune monitoring suggest that KD may have multiple triggers that stimulate different arms of the innate and adaptive compartment in KD patients. Thus, it is possible that diverse antigens may participate in the pathogenesis of KD. |Acute Disease[MESH] |Antigens/*blood/immunology[MESH] |Child[MESH] |Child, Preschool[MESH] |Dendritic Cells/immunology/*metabolism[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulins, Intravenous/administration & dosage[MESH] |Infant[MESH] |Lymphocytes/immunology/*metabolism[MESH] |Male[MESH]Characterization of circulating immune cells in acute Kawasaki disease(epmc).pdf DeepDyve Pubget Overpricing