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10.1038/s41591-020-1054-6

http://scihub22266oqcxt.onion/10.1038/s41591-020-1054-6
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32812012!ä!32812012

suck abstract from ncbi


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pmid32812012      Nat+Med 2020 ; 26 (11): 1701-1707
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  • Peripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infection #MMPMID32812012
  • Carter MJ; Fish M; Jennings A; Doores KJ; Wellman P; Seow J; Acors S; Graham C; Timms E; Kenny J; Neil S; Malim MH; Tibby SM; Shankar-Hari M
  • Nat Med 2020[Nov]; 26 (11): 1701-1707 PMID32812012show ga
  • Recent reports highlight a new clinical syndrome in children related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)(1)-multisystem inflammatory syndrome in children (MIS-C)-which comprises multiorgan dysfunction and systemic inflammation(2-13). We performed peripheral leukocyte phenotyping in 25 children with MIS-C, in the acute (n = 23; worst illness within 72 h of admission), resolution (n = 14; clinical improvement) and convalescent (n = 10; first outpatient visit) phases of the illness and used samples from seven age-matched healthy controls for comparisons. Among the MIS-C cohort, 17 (68%) children were SARS-CoV-2 seropositive, suggesting previous SARS-CoV-2 infections(14,15), and these children had more severe disease. In the acute phase of MIS-C, we observed high levels of interleukin-1beta (IL-1beta), IL-6, IL-8, IL-10, IL-17, interferon-gamma and differential T and B cell subset lymphopenia. High CD64 expression on neutrophils and monocytes, and high HLA-DR expression on gammadelta and CD4(+)CCR7(+) T cells in the acute phase, suggested that these immune cell populations were activated. Antigen-presenting cells had low HLA-DR and CD86 expression, potentially indicative of impaired antigen presentation. These features normalized over the resolution and convalescence phases. Overall, MIS-C presents as an immunopathogenic illness(1) and appears distinct from Kawasaki disease.
  • |Adolescent[MESH]
  • |Age of Onset[MESH]
  • |Blood Coagulation/physiology[MESH]
  • |COVID-19/*blood/complications/epidemiology/*immunology[MESH]
  • |Cardiomyopathies/blood/etiology/immunology[MESH]
  • |Case-Control Studies[MESH]
  • |Child[MESH]
  • |Child, Preschool[MESH]
  • |Cohort Studies[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunophenotyping[MESH]
  • |Inflammation/blood/etiology/immunology[MESH]
  • |Leukocytes/*classification/immunology/*pathology[MESH]
  • |Male[MESH]
  • |SARS-CoV-2/*immunology[MESH]


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