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10.1186/s12985-020-01396-w http://scihub22266oqcxt.onion/10.1186/s12985-020-01396-w 32811514!7431901!32811514     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32811514&cmd=llinks): Failed to open stream: HTTP request failed! 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Intranasal exposure of African green monkeys to SARS-CoV-2 results in acute phase pneumonia with shedding and lung injury still present in the early convalescence phase |pdf=|usr=}}{{32811514}} gab.com Text Intranasal exposure of African green monkeys to SARS-CoV-2 results in acute phase pneumonia with shedding and lung injury still present in the early convalescence phase JO: Virol J http://www.kidney.de/pget.php?&tw=1&pmid=32811514 #FOAvip We recently reported the development of the first African green monkey (AGM) model for COVID-19 based on a combined liquid intranasal (i.n.) and intratracheal (i.t.) exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we followed up on this work by assessing an i.n. particle only route of exposure using the LMA mucosal atomization device (MAD). Six AGMs were infected with SARS-CoV-2; three animals were euthanized near the peak stage of virus replication (day 5) and three animals were euthanized during the early convalescence period (day 34). All six AGMs supported robust SARS-CoV-2 replication and developed respiratory disease. Evidence of coagulation dysfunction as noted by a transient increases in aPTT and circulating levels of fibrinogen was observed in all AGMs. The level of SARS-CoV-2 replication and lung pathology was not quite as pronounced as previously reported with AGMs exposed by the combined i.n. and i.t. routes; however, SARS-CoV-2 RNA was detected in nasal swabs of some animals as late as day 15 and rectal swabs as late as day 28 after virus challenge. Of particular importance to this study, all three AGMs that were followed until the early convalescence stage of COVID-19 showed substantial lung pathology at necropsy as evidenced by multifocal chronic interstitial pneumonia and increased collagen deposition in alveolar walls despite the absence of detectable SARS-CoV-2 in any of the lungs of these animals. These findings are consistent with human COVID-19 further demonstrating that the AGM faithfully reproduces the human condition. Twit Text FOAVip Intranasal exposure of African green monkeys to SARS-CoV-2 results in acute phase pneumonia with shedding and lung injury still present in the early convalescence phase ????Virol J http://www.kidney.de/pget.php?&tw=1&pmid=32811514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32811514 #FOAvip English Wikipedia <ref>{{Cite pmid|32811514}}</ref> Intranasal exposure of African green monkeys to SARS-CoV-2 results in acute phase pneumonia with shedding and lung injury still present in the early convalescence phase #MMPMID32811514 Cross RW; Agans KN; Prasad AN; Borisevich V; Woolsey C; Deer DJ; Dobias NS; Geisbert JB; Fenton KA; Geisbert TW Virol J 2020[Aug]; 17 (1): 125 PMID32811514show ga We recently reported the development of the first African green monkey (AGM) model for COVID-19 based on a combined liquid intranasal (i.n.) and intratracheal (i.t.) exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we followed up on this work by assessing an i.n. particle only route of exposure using the LMA mucosal atomization device (MAD). Six AGMs were infected with SARS-CoV-2; three animals were euthanized near the peak stage of virus replication (day 5) and three animals were euthanized during the early convalescence period (day 34). All six AGMs supported robust SARS-CoV-2 replication and developed respiratory disease. Evidence of coagulation dysfunction as noted by a transient increases in aPTT and circulating levels of fibrinogen was observed in all AGMs. The level of SARS-CoV-2 replication and lung pathology was not quite as pronounced as previously reported with AGMs exposed by the combined i.n. and i.t. routes; however, SARS-CoV-2 RNA was detected in nasal swabs of some animals as late as day 15 and rectal swabs as late as day 28 after virus challenge. Of particular importance to this study, all three AGMs that were followed until the early convalescence stage of COVID-19 showed substantial lung pathology at necropsy as evidenced by multifocal chronic interstitial pneumonia and increased collagen deposition in alveolar walls despite the absence of detectable SARS-CoV-2 in any of the lungs of these animals. These findings are consistent with human COVID-19 further demonstrating that the AGM faithfully reproduces the human condition. |Animals[MESH] |Betacoronavirus/immunology/*pathogenicity[MESH] |COVID-19[MESH] |Chlorocebus aethiops[MESH] |Convalescence[MESH] |Coronavirus Infections/blood/*pathology/*virology[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Lung Injury/pathology/virology[MESH] |Nasal Mucosa/virology[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*pathology/*virology[MESH] |SARS-CoV-2[MESH] |Seroconversion[MESH] |Viral Load[MESH]Intranasal exposure of African green monkeys to SARS-CoV-2 results in (epmc).pdf DeepDyve Pubget Overpricing