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10.1080/07391102.2020.1809522 http://scihub22266oqcxt.onion/10.1080/07391102.2020.1809522 32811367!7484577!32811367     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32811367.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biomol+Struct+Dyn 2022 ; 40 (1): 136-142 Nephropedia Template TP {{tp|p=32811367|t=2022. An in-silico evaluation of dietary components for structural inhibition of SARS-Cov-2 main protease |pdf=|usr=}}{{32811367}} gab.com Text An in-silico evaluation of dietary components for structural inhibition of SARS-Cov-2 main protease JO: J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=32811367 #FOAvip The main protease (M(pro)) of SARS-CoV-2 is responsible for the cleavage of viral replicase polyproteins 1a and 1ab into their mature form and is highly specific and exclusive in its activity. Many studies have targeted this enzyme by small molecule inhibitors to develop therapeutics against the highly infectious disease Covid-19. Our diet contains many natural antioxidants which along with providing support for proper growth and functioning of the body, pose additional health benefits. Present in-silico analysis depicted that natural antioxidants like sesamin, ellagic acid, capsaisin, and epicatechin along with galangin, exhibited significant binding at the catalytic site of the M(pro) enzyme. They interacted with excellent efficiency with the chief active site residue Cys145 and thus seem to possess the remarkable potential to act as drug candidates for the treatment of Covid-19. Such dietary compounds can be easily administered orally with least toxicity related concern and thus yell for urgent exhaustive research to develop into efficient therapies.Communicated by Ramaswamy H. Sarma. Twit Text FOAVip An in-silico evaluation of dietary components for structural inhibition of SARS-Cov-2 main protease ????J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=32811367 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32811367 #FOAvip English Wikipedia <ref>{{Cite pmid|32811367}}</ref> An in-silico evaluation of dietary components for structural inhibition of SARS-Cov-2 main protease #MMPMID32811367 Pandey AK; Verma S J Biomol Struct Dyn 2022[Jan]; 40 (1): 136-142 PMID32811367show ga The main protease (M(pro)) of SARS-CoV-2 is responsible for the cleavage of viral replicase polyproteins 1a and 1ab into their mature form and is highly specific and exclusive in its activity. Many studies have targeted this enzyme by small molecule inhibitors to develop therapeutics against the highly infectious disease Covid-19. Our diet contains many natural antioxidants which along with providing support for proper growth and functioning of the body, pose additional health benefits. Present in-silico analysis depicted that natural antioxidants like sesamin, ellagic acid, capsaisin, and epicatechin along with galangin, exhibited significant binding at the catalytic site of the M(pro) enzyme. They interacted with excellent efficiency with the chief active site residue Cys145 and thus seem to possess the remarkable potential to act as drug candidates for the treatment of Covid-19. Such dietary compounds can be easily administered orally with least toxicity related concern and thus yell for urgent exhaustive research to develop into efficient therapies.Communicated by Ramaswamy H. Sarma. |*COVID-19[MESH] |*Diet[MESH] |*Protease Inhibitors/pharmacology[MESH] |Antioxidants/pharmacology[MESH] |Coronavirus 3C Proteases/*antagonists & inhibitors[MESH] |Humans[MESH] |Molecular Docking Simulation[MESH] |Molecular Dynamics Simulation[MESH]An in-silico evaluation of dietary components for structural inhibitio(epmc).pdf DeepDyve Pubget Overpricing