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10.1016/j.clim.2020.108572 http://scihub22266oqcxt.onion/10.1016/j.clim.2020.108572 32810602!7428760!32810602     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Immunol 2020 ; 219 (ä): 108572 Nephropedia Template TP {{tp|p=32810602|t=2020. Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients |pdf=|usr=}}{{32810602}} gab.com Text Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32810602 #FOAvip Human Leukocyte Antigen (HLA) includes a large set of genes with important actions in immune response against viral infection. Numerous studies have revealed the existence of significant associations between certain HLA alleles and the susceptibility and prognosis of different infectious diseases. In this pilot study we analyse the binding affinity between 66 class I HLA alleles and SARS-CoV-2 viral peptides, and its association with the severity of the disease. A total of 45 Spanish patients with mild, moderate and severe SARS-CoV-2 infection were typed for HLA class I; after that, we analysed if an in silico model of HLA I-viral peptide binding affinity and classical HLA supertypes could be correlated to the severity of the disease. Our results suggest that patients with mild disease present Class I HLA molecules with a higher theoretical capacity for binding SARS-Cov-2 peptides and showed greater heterozygosity when comparing them with moderate and severe groups. In this regard, identifying HLA-SARS-CoV-2 peptides binding differences between individuals would help to clarify the heterogeneity of clinical responses to the disease and will also be useful to guide a personalized treatment according to its particular risk. Twit Text FOAVip Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32810602 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32810602 #FOAvip English Wikipedia <ref>{{Cite pmid|32810602}}</ref> Possible role of HLA class-I genotype in SARS-CoV-2 infection and progression: A pilot study in a cohort of Covid-19 Spanish patients #MMPMID32810602 Iturrieta-Zuazo I; Rita CG; Garcia-Soidan A; de Malet Pintos-Fonseca A; Alonso-Alarcon N; Pariente-Rodriguez R; Tejeda-Velarde A; Serrano-Villar S; Castaner-Alabau JL; Nieto-Ganan I Clin Immunol 2020[Oct]; 219 (ä): 108572 PMID32810602show ga Human Leukocyte Antigen (HLA) includes a large set of genes with important actions in immune response against viral infection. Numerous studies have revealed the existence of significant associations between certain HLA alleles and the susceptibility and prognosis of different infectious diseases. In this pilot study we analyse the binding affinity between 66 class I HLA alleles and SARS-CoV-2 viral peptides, and its association with the severity of the disease. A total of 45 Spanish patients with mild, moderate and severe SARS-CoV-2 infection were typed for HLA class I; after that, we analysed if an in silico model of HLA I-viral peptide binding affinity and classical HLA supertypes could be correlated to the severity of the disease. Our results suggest that patients with mild disease present Class I HLA molecules with a higher theoretical capacity for binding SARS-Cov-2 peptides and showed greater heterozygosity when comparing them with moderate and severe groups. In this regard, identifying HLA-SARS-CoV-2 peptides binding differences between individuals would help to clarify the heterogeneity of clinical responses to the disease and will also be useful to guide a personalized treatment according to its particular risk. |Adult[MESH] |Aged[MESH] |Alleles[MESH] |Betacoronavirus/immunology/*pathogenicity[MESH] |COVID-19[MESH] |Coronavirus Infections/*genetics/immunology/pathology/virology[MESH] |Disease Progression[MESH] |Female[MESH] |Gene Expression[MESH] |Gene Frequency[MESH] |Histocompatibility Antigens Class I/classification/*genetics/immunology[MESH] |Host-Pathogen Interactions/*immunology[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Peptides/genetics/immunology[MESH] |Pilot Projects[MESH] |Pneumonia, Viral/*genetics/immunology/pathology/virology[MESH] |Protein Binding[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH] |Spain[MESH]Possible role of HLA class-I genotype in SARS-CoV-2 infection and prog(epmc).pdf DeepDyve Pubget Overpricing