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10.1016/j.cell.2020.08.002 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.08.002 32810439!7405878!32810439     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 182 (6): 1401-1418.e18 Nephropedia Template TP {{tp|p=32810439|t=2020. Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19 |pdf=|usr=}}{{32810439}} gab.com Text Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19 JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32810439 #FOAvip Blood myeloid cells are known to be dysregulated in coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2. It is unknown whether the innate myeloid response differs with disease severity and whether markers of innate immunity discriminate high-risk patients. Thus, we performed high-dimensional flow cytometry and single-cell RNA sequencing of COVID-19 patient peripheral blood cells and detected disappearance of non-classical CD14(Low)CD16(High) monocytes, accumulation of HLA-DR(Low) classical monocytes (Human Leukocyte Antigen - DR isotype), and release of massive amounts of calprotectin (S100A8/S100A9) in severe cases. Immature CD10(Low)CD101(-)CXCR4(+/-) neutrophils with an immunosuppressive profile accumulated in the blood and lungs, suggesting emergency myelopoiesis. Finally, we show that calprotectin plasma level and a routine flow cytometry assay detecting decreased frequencies of non-classical monocytes could discriminate patients who develop a severe form of COVID-19, suggesting a predictive value that deserves prospective evaluation. Twit Text FOAVip Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19 ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32810439 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32810439 #FOAvip English Wikipedia <ref>{{Cite pmid|32810439}}</ref> Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19 #MMPMID32810439 Silvin A; Chapuis N; Dunsmore G; Goubet AG; Dubuisson A; Derosa L; Almire C; Henon C; Kosmider O; Droin N; Rameau P; Catelain C; Alfaro A; Dussiau C; Friedrich C; Sourdeau E; Marin N; Szwebel TA; Cantin D; Mouthon L; Borderie D; Deloger M; Bredel D; Mouraud S; Drubay D; Andrieu M; Lhonneur AS; Saada V; Stoclin A; Willekens C; Pommeret F; Griscelli F; Ng LG; Zhang Z; Bost P; Amit I; Barlesi F; Marabelle A; Pene F; Gachot B; Andre F; Zitvogel L; Ginhoux F; Fontenay M; Solary E Cell 2020[Sep]; 182 (6): 1401-1418.e18 PMID32810439show ga Blood myeloid cells are known to be dysregulated in coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2. It is unknown whether the innate myeloid response differs with disease severity and whether markers of innate immunity discriminate high-risk patients. Thus, we performed high-dimensional flow cytometry and single-cell RNA sequencing of COVID-19 patient peripheral blood cells and detected disappearance of non-classical CD14(Low)CD16(High) monocytes, accumulation of HLA-DR(Low) classical monocytes (Human Leukocyte Antigen - DR isotype), and release of massive amounts of calprotectin (S100A8/S100A9) in severe cases. Immature CD10(Low)CD101(-)CXCR4(+/-) neutrophils with an immunosuppressive profile accumulated in the blood and lungs, suggesting emergency myelopoiesis. Finally, we show that calprotectin plasma level and a routine flow cytometry assay detecting decreased frequencies of non-classical monocytes could discriminate patients who develop a severe form of COVID-19, suggesting a predictive value that deserves prospective evaluation. |*Coronavirus[MESH] |*Coronavirus Infections[MESH] |*Pandemics[MESH] |*Pneumonia, Viral[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Flow Cytometry[MESH] |Humans[MESH] |Leukocyte L1 Antigen Complex[MESH] |Monocytes[MESH] |Myeloid Cells[MESH] |Prospective Studies[MESH]Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate S(epmc).pdf DeepDyve Pubget Overpricing