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10.1016/j.cell.2020.08.001 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.08.001 32810438!7405822!32810438     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 182 (6): 1419-1440.e23 Nephropedia Template TP {{tp|p=32810438|t=2020. Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment |pdf=|usr=}}{{32810438}} gab.com Text Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32810438 #FOAvip Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DR(hi)CD11c(hi) inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DR(lo) monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19. Twit Text FOAVip Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32810438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32810438 #FOAvip English Wikipedia <ref>{{Cite pmid|32810438}}</ref> Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment #MMPMID32810438 Schulte-Schrepping J; Reusch N; Paclik D; Bassler K; Schlickeiser S; Zhang B; Kramer B; Krammer T; Brumhard S; Bonaguro L; De Domenico E; Wendisch D; Grasshoff M; Kapellos TS; Beckstette M; Pecht T; Saglam A; Dietrich O; Mei HE; Schulz AR; Conrad C; Kunkel D; Vafadarnejad E; Xu CJ; Horne A; Herbert M; Drews A; Thibeault C; Pfeiffer M; Hippenstiel S; Hocke A; Muller-Redetzky H; Heim KM; Machleidt F; Uhrig A; Bosquillon de Jarcy L; Jurgens L; Stegemann M; Glosenkamp CR; Volk HD; Goffinet C; Landthaler M; Wyler E; Georg P; Schneider M; Dang-Heine C; Neuwinger N; Kappert K; Tauber R; Corman V; Raabe J; Kaiser KM; Vinh MT; Rieke G; Meisel C; Ulas T; Becker M; Geffers R; Witzenrath M; Drosten C; Suttorp N; von Kalle C; Kurth F; Handler K; Schultze JL; Aschenbrenner AC; Li Y; Nattermann J; Sawitzki B; Saliba AE; Sander LE Cell 2020[Sep]; 182 (6): 1419-1440.e23 PMID32810438show ga Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell proteomics of whole-blood and peripheral-blood mononuclear cells to determine changes in immune cell composition and activation in mild versus severe COVID-19 (242 samples from 109 individuals) over time. HLA-DR(hi)CD11c(hi) inflammatory monocytes with an interferon-stimulated gene signature were elevated in mild COVID-19. Severe COVID-19 was marked by occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DR(lo) monocytes. Our study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and reveals profound alterations in the myeloid cell compartment associated with severe COVID-19. |*Myelopoiesis[MESH] |Adult[MESH] |Aged[MESH] |CD11 Antigens/genetics/metabolism[MESH] |COVID-19[MESH] |Cells, Cultured[MESH] |Coronavirus Infections/blood/*immunology/pathology[MESH] |Female[MESH] |HLA-DR Antigens/genetics/metabolism[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Myeloid Cells/cytology/*immunology[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*immunology/pathology[MESH] |Proteome/genetics/metabolism[MESH] |Proteomics[MESH]Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment (epmc).pdf DeepDyve Pubget Overpricing