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10.1152/physiolgenomics.00095.2020

http://scihub22266oqcxt.onion/10.1152/physiolgenomics.00095.2020
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suck abstract from ncbi


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pmid32809918      Physiol+Genomics 2020 ; 52 (9): 401-407
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  • Oxytocin s anti-inflammatory and proimmune functions in COVID-19: a transcriptomic signature-based approach #MMPMID32809918
  • Imami AS; O'Donovan SM; Creeden JF; Wu X; Eby H; McCullumsmith CB; Uvnas-Moberg K; McCullumsmith RE; Andari E
  • Physiol Genomics 2020[Sep]; 52 (9): 401-407 PMID32809918show ga
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide pandemic, infecting over 16 million people worldwide with a significant mortality rate. However, there is no current Food and Drug Administration-approved drug that treats coronavirus disease 2019 (COVID-19). Damage to T lymphocytes along with the cytokine storm are important factors that lead to exacerbation of clinical cases. Here, we are proposing intravenous oxytocin (OXT) as a candidate for adjunctive therapy for COVID-19. OXT has anti-inflammatory and proimmune adaptive functions. Using the Library of Integrated Network-Based Cellular Signatures (LINCS), we used the transcriptomic signature for carbetocin, an OXT agonist, and compared it to gene knockdown signatures of inflammatory (such as interleukin IL-1beta and IL-6) and proimmune markers (including T cell and macrophage cell markers like CD40 and ARG1). We found that carbetocin's transcriptomic signature has a pattern of concordance with inflammation and immune marker knockdown signatures that are consistent with reduction of inflammation and promotion and sustaining of immune response. This suggests that carbetocin may have potent effects in modulating inflammation, attenuating T cell inhibition, and enhancing T cell activation. Our results also suggest that carbetocin is more effective at inducing immune cell responses than either lopinavir or hydroxychloroquine, both of which have been explored for the treatment of COVID-19.
  • |*Gene Expression Profiling[MESH]
  • |Adaptive Immunity/*drug effects/genetics[MESH]
  • |Anti-Inflammatory Agents/*pharmacology[MESH]
  • |Betacoronavirus/*drug effects/immunology[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Cell Line[MESH]
  • |Coronavirus Infections/*drug therapy/genetics/immunology/virology[MESH]
  • |Databases, Genetic[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Oxytocin/*analogs & derivatives/pharmacology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/genetics/immunology/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |T-Lymphocytes/*drug effects/immunology/virology[MESH]


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