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10.1080/14787210.2020.1808462

http://scihub22266oqcxt.onion/10.1080/14787210.2020.1808462
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32809870!ä!32809870

suck abstract from ncbi


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pmid32809870      Expert+Rev+Anti+Infect+Ther 2021 ; 19 (2): 129-135
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  • MATH+ protocol for the treatment of SARS-CoV-2 infection: the scientific rationale #MMPMID32809870
  • Marik PE; Kory P; Varon J; Iglesias J; Meduri GU
  • Expert Rev Anti Infect Ther 2021[Feb]; 19 (2): 129-135 PMID32809870show ga
  • INTRODUCTION: COVID-19 disease progresses through a number of distinct phases. The management of each phase is unique and specific. The pulmonary phase of COVID-19 is characterized by an organizing pneumonia with profound immune dysregulation, activation of clotting, and a severe microvascular injury culminating in severe hypoxemia. The core treatment strategy to manage the pulmonary phase includes the combination of methylprednisolone, ascorbic acid, thiamine, and heparin (MATH+ protocol). The rationale for the MATH+ protocol is reviewed in this paper. AREAS COVERED: We provide an overview on the pathophysiological changes occurring in patients with COVID-19 respiratory failure and a treatment strategy to reverse these changes thereby preventing progressive lung injury and death. EXPERT OPINION: While there is no single 'Silver Bullet' to cure COVID-19, we believe that the severely disturbed pathological processes leading to respiratory failure in patients with COVID-19 organizing pneumonia will respond to the combination of Methylprednisone, Ascorbic acid, Thiamine, and full anticoagulation with Heparin (MATH+ protocol).We believe that it is no longer ethically acceptable to limit management to 'supportive care' alone, in the face of effective, safe, and inexpensive medications that can effectively treat this disease and thereby reduce the risk of complications and death.
  • |*COVID-19 Drug Treatment[MESH]
  • |*COVID-19/blood/metabolism/physiopathology[MESH]
  • |*Clinical Protocols[MESH]
  • |Anti-Inflammatory Agents/pharmacology[MESH]
  • |Anticoagulants/pharmacology[MESH]
  • |Ascorbic Acid/*pharmacology[MESH]
  • |Heparin/*pharmacology[MESH]
  • |Humans[MESH]
  • |Methylprednisolone/*pharmacology[MESH]
  • |Patient Acuity[MESH]
  • |SARS-CoV-2[MESH]
  • |Thiamine/*pharmacology[MESH]


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