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10.1007/s00259-020-04999-1

http://scihub22266oqcxt.onion/10.1007/s00259-020-04999-1
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suck abstract from ncbi


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pmid32808079      Eur+J+Nucl+Med+Mol+Imaging 2021 ; 48 (1): 282-286
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  • CT abnormalities evocative of lung infection are associated with lower (18)F-FDG uptake in confirmed COVID-19 patients #MMPMID32808079
  • Bahloul A; Boursier C; Jeulin H; Imbert L; Mandry D; Karcher G; Marie PY; Verger A
  • Eur J Nucl Med Mol Imaging 2021[Jan]; 48 (1): 282-286 PMID32808079show ga
  • PURPOSE: CT signs that are evocative of lung COVID-19 infections have been extensively described, whereas (18)F-FDG-PET signs have not. Our current study aimed to identify specific COVID-19 (18)F-FDG-PET signs in patients that were (i) suspected to have a lung infection based on (18)F-FDG-PET/CT recorded during the COVID-19 outbreak and (ii) whose COVID-19 diagnosis was definitely established or excluded by appropriate viral testing. METHODS: Twenty-two consecutive patients referred for routine (18)F-FDG-PET/CT examinations during the COVID-19 outbreak (March 25th to May 15th 2020) and for whom CT slices were evocative of a lung infection were included in the study. All patients had undergone a SARS-COV-2 diagnostic test to confirm COVID-19 infection (positivity was based on molecular and/or serological tests) or exclude it (negativity of at least the serological test). RESULTS: Eleven patients were confirmed to be affected by COVID-19 (COVID+), whereas the other eleven patients were not (COVID-) and were predominantly suspected of having bacterial pneumonia. CT abnormalities were not significantly different between COVID+ and COVID- groups, although trends toward larger CT abnormalities (p = 0.16) and lower rates of consolidation patterns (0.09) were observed in the COVID+ group. The maximal standardized uptake values (SUV(max)) of lung areas with CT abnormalities were however significantly lower in the COVID+ than the COVID- group (3.7 +/- 1.9 vs. 6.9 +/- 4.1, p = 0.03), with the highest SUV(max) consistently not associated with COVID-19. CONCLUSION: Among CT abnormalities evocative of lung infection, those related to COVID-19 are associated with a more limited (18)F-FDG uptake. This observation may help improve our ability to detect COVID-19 patients.
  • |*Fluorodeoxyglucose F18[MESH]
  • |*Radiopharmaceuticals[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |COVID-19 Nucleic Acid Testing[MESH]
  • |COVID-19 Serological Testing[MESH]
  • |COVID-19/diagnosis/*diagnostic imaging[MESH]
  • |Diagnosis, Differential[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lung/*diagnostic imaging[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]


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