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10.1038/s41590-020-0773-7 http://scihub22266oqcxt.onion/10.1038/s41590-020-0773-7 32807944!ä!32807944 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32807944&cmd=llinks): Failed to open stream: HTTP request failed! 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ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection |pdf=|usr=}}{{32807944}} gab.com Text ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32807944 #FOAvip The SARS-CoV-2 virus emerged in December 2019 and has caused a worldwide pandemic due to the lack of any pre-existing immunity. Accurate serology testing is urgently needed to help diagnose infection, determine past exposure of populations and assess the response to a future vaccine. The landscape of antibody responses to SARS-CoV-2 is unknown. In this study, we utilized the luciferase immunoprecipitation system to assess the antibody responses to 15 different SARS-CoV-2 antigens in patients with COVID-19. We identified new targets of the immune response to SARS-CoV-2 and show that nucleocapsid, open reading frame (ORF)8 and ORF3b elicit the strongest specific antibody responses. ORF8 and ORF3b antibodies, taken together as a cluster of points, identified 96.5% of COVID-19 samples at early and late time points of disease with 99.5% specificity. Our findings could be used to develop second-generation diagnostic tests to improve serological assays for COVID-19 and are important in understanding pathogenicity. Twit Text FOAVip ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32807944 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32807944 #FOAvip English Wikipedia <ref>{{Cite pmid|32807944}}</ref> ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection #MMPMID32807944 Hachim A; Kavian N; Cohen CA; Chin AWH; Chu DKW; Mok CKP; Tsang OTY; Yeung YC; Perera RAPM; Poon LLM; Peiris JSM; Valkenburg SA Nat Immunol 2020[Oct]; 21 (10): 1293-1301 PMID32807944show ga The SARS-CoV-2 virus emerged in December 2019 and has caused a worldwide pandemic due to the lack of any pre-existing immunity. Accurate serology testing is urgently needed to help diagnose infection, determine past exposure of populations and assess the response to a future vaccine. The landscape of antibody responses to SARS-CoV-2 is unknown. In this study, we utilized the luciferase immunoprecipitation system to assess the antibody responses to 15 different SARS-CoV-2 antigens in patients with COVID-19. We identified new targets of the immune response to SARS-CoV-2 and show that nucleocapsid, open reading frame (ORF)8 and ORF3b elicit the strongest specific antibody responses. ORF8 and ORF3b antibodies, taken together as a cluster of points, identified 96.5% of COVID-19 samples at early and late time points of disease with 99.5% specificity. Our findings could be used to develop second-generation diagnostic tests to improve serological assays for COVID-19 and are important in understanding pathogenicity. |Adult[MESH] |Aged[MESH] |Antibodies, Viral/*blood/immunology[MESH] |Antigens, Viral/immunology[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |COVID-19 Testing[MESH] |Clinical Laboratory Techniques/*methods[MESH] |Coronavirus Infections/blood/*diagnosis/immunology/virology[MESH] |Female[MESH] |Hong Kong[MESH] |Humans[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*diagnosis/immunology/virology[MESH] |SARS-CoV-2[MESH] |Sensitivity and Specificity[MESH] |Time Factors[MESH]ORF8 and ORF3b antibodies are accurate serological markers of early an(epmc).pdf DeepDyve Pubget Overpricing