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10.1038/s41591-020-1038-6 http://scihub22266oqcxt.onion/10.1038/s41591-020-1038-6 32807934!ä!32807934 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32807934.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Med 2020 ; 26 (10): 1623-1635 Nephropedia Template TP {{tp|p=32807934|t=2020. A dynamic COVID-19 immune signature includes associations with poor prognosis |pdf=|usr=}}{{32807934}} gab.com Text A dynamic COVID-19 immune signature includes associations with poor prognosis JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=32807934 #FOAvip Improved understanding and management of COVID-19, a potentially life-threatening disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward this end, we have identified a core peripheral blood immune signature across 63 hospital-treated patients with COVID-19 who were otherwise highly heterogeneous. The signature includes discrete changes in B and myelomonocytic cell composition, profoundly altered T cell phenotypes, selective cytokine/chemokine upregulation and SARS-CoV-2-specific antibodies. Some signature traits identify links with other settings of immunoprotection and immunopathology; others, including basophil and plasmacytoid dendritic cell depletion, correlate strongly with disease severity; while a third set of traits, including a triad of IP-10, interleukin-10 and interleukin-6, anticipate subsequent clinical progression. Hence, contingent upon independent validation in other COVID-19 cohorts, individual traits within this signature may collectively and individually guide treatment options; offer insights into COVID-19 pathogenesis; and aid early, risk-based patient stratification that is particularly beneficial in phasic diseases such as COVID-19. Twit Text FOAVip A dynamic COVID-19 immune signature includes associations with poor prognosis ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=32807934 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32807934 #FOAvip English Wikipedia <ref>{{Cite pmid|32807934}}</ref> A dynamic COVID-19 immune signature includes associations with poor prognosis #MMPMID32807934 Laing AG; Lorenc A; Del Molino Del Barrio I; Das A; Fish M; Monin L; Munoz-Ruiz M; McKenzie DR; Hayday TS; Francos-Quijorna I; Kamdar S; Joseph M; Davies D; Davis R; Jennings A; Zlatareva I; Vantourout P; Wu Y; Sofra V; Cano F; Greco M; Theodoridis E; Freedman JD; Gee S; Chan JNE; Ryan S; Bugallo-Blanco E; Peterson P; Kisand K; Haljasmagi L; Chadli L; Moingeon P; Martinez L; Merrick B; Bisnauthsing K; Brooks K; Ibrahim MAA; Mason J; Lopez Gomez F; Babalola K; Abdul-Jawad S; Cason J; Mant C; Seow J; Graham C; Doores KJ; Di Rosa F; Edgeworth J; Shankar-Hari M; Hayday AC Nat Med 2020[Oct]; 26 (10): 1623-1635 PMID32807934show ga Improved understanding and management of COVID-19, a potentially life-threatening disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward this end, we have identified a core peripheral blood immune signature across 63 hospital-treated patients with COVID-19 who were otherwise highly heterogeneous. The signature includes discrete changes in B and myelomonocytic cell composition, profoundly altered T cell phenotypes, selective cytokine/chemokine upregulation and SARS-CoV-2-specific antibodies. Some signature traits identify links with other settings of immunoprotection and immunopathology; others, including basophil and plasmacytoid dendritic cell depletion, correlate strongly with disease severity; while a third set of traits, including a triad of IP-10, interleukin-10 and interleukin-6, anticipate subsequent clinical progression. Hence, contingent upon independent validation in other COVID-19 cohorts, individual traits within this signature may collectively and individually guide treatment options; offer insights into COVID-19 pathogenesis; and aid early, risk-based patient stratification that is particularly beneficial in phasic diseases such as COVID-19. |Aged[MESH] |Antibodies, Viral/*immunology[MESH] |B-Lymphocyte Subsets/immunology[MESH] |B-Lymphocytes/*immunology[MESH] |Basophils/immunology[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Case-Control Studies[MESH] |Cell Cycle[MESH] |Chemokine CXCL10/immunology[MESH] |Chemokines/immunology[MESH] |Cohort Studies[MESH] |Coronavirus Infections/blood/*immunology[MESH] |Cytokines/*immunology[MESH] |Dendritic Cells/*immunology[MESH] |Disease Progression[MESH] |Female[MESH] |Flow Cytometry[MESH] |Hospitalization[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Immunophenotyping[MESH] |Interleukin-10/immunology[MESH] |Interleukin-6/immunology[MESH] |Leukocyte Count[MESH] |Lymphocyte Activation/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/blood/*immunology[MESH] |Prognosis[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH] |T-Lymphocyte Subsets/immunology[MESH] |T-Lymphocytes/*immunology[MESH]A dynamic COVID-19 immune signature includes associations with poor pr(epmc).pdf DeepDyve Pubget Overpricing