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10.1038/s41598-020-70623-9

http://scihub22266oqcxt.onion/10.1038/s41598-020-70623-9
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32807805!7431535!32807805
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suck abstract from ncbi


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pmid32807805      Sci+Rep 2020 ; 10 (1): 13875
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  • Salt coatings functionalize inert membranes into high-performing filters against infectious respiratory diseases #MMPMID32807805
  • Rubino I; Oh E; Han S; Kaleem S; Hornig A; Lee SH; Kang HJ; Lee DH; Chu KB; Kumaran S; Armstrong S; Lalani R; Choudhry S; Kim CI; Quan FS; Jeon B; Choi HJ
  • Sci Rep 2020[Aug]; 10 (1): 13875 PMID32807805show ga
  • Respiratory protection is key in infection prevention of airborne diseases, as highlighted by the COVID-19 pandemic for instance. Conventional technologies have several drawbacks (i.e., cross-infection risk, filtration efficiency improvements limited by difficulty in breathing, and no safe reusability), which have yet to be addressed in a single device. Here, we report the development of a filter overcoming the major technical challenges of respiratory protective devices. Large-pore membranes, offering high breathability but low bacteria capture, were functionalized to have a uniform salt layer on the fibers. The salt-functionalized membranes achieved high filtration efficiency as opposed to the bare membrane, with differences of up to 48%, while maintaining high breathability (> 60% increase compared to commercial surgical masks even for the thickest salt filters tested). The salt-functionalized filters quickly killed Gram-positive and Gram-negative bacteria aerosols in vitro, with CFU reductions observed as early as within 5 min, and in vivo by causing structural damage due to salt recrystallization. The salt coatings retained the pathogen inactivation capability at harsh environmental conditions (37 degrees C and a relative humidity of 70%, 80% and 90%). Combination of these properties in one filter will lead to the production of an effective device, comprehensibly mitigating infection transmission globally.
  • |*Betacoronavirus[MESH]
  • |*Membranes, Artificial[MESH]
  • |Aerosols[MESH]
  • |Air Filters/*microbiology[MESH]
  • |Anti-Bacterial Agents/*chemistry/pharmacology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*prevention & control/transmission/virology[MESH]
  • |Crystallization[MESH]
  • |Gram-Negative Bacteria/drug effects[MESH]
  • |Gram-Positive Bacteria/drug effects[MESH]
  • |Hot Temperature[MESH]
  • |Humans[MESH]
  • |Humidity[MESH]
  • |Masks/*microbiology[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/*prevention & control/transmission/virology[MESH]
  • |Respiratory Protective Devices/*microbiology[MESH]
  • |SARS-CoV-2[MESH]


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