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10.1111/cas.14618 http://scihub22266oqcxt.onion/10.1111/cas.14618 32805774!7461281!32805774     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Sci 2020 ; 111 (11): 3976-3984 Nephropedia Template TP {{tp|p=32805774|t=2020. RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID-19 |pdf=|usr=}}{{32805774}} gab.com Text RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID-19 JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=32805774 #FOAvip A recent outbreak of coronavirus disease (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 has driven a global pandemic with catastrophic consequences. The rapid development of promising therapeutic strategies against COVID-19 is keenly anticipated. Family Coronaviridae comprises positive, single-stranded RNA viruses that use RNA-dependent RNA polymerase (RdRP) for viral replication and transcription. As the RdRP of viruses in this family and others plays a pivotal role in infection, it is a promising therapeutic target for developing antiviral agents against them. A critical genetic driver for many cancers is the catalytic subunit of telomerase: human telomerase reverse transcriptase (hTERT), identified initially as an RNA-dependent DNA polymerase. However, even though hTERT is a DNA polymerase, it has phylogenetic and structural similarities to viral RdRPs. Researchers worldwide, including the authors of this review, are engaged in developing therapeutic strategies targeting hTERT. We have published a series of papers reporting that hTERT has RdRP activity and that this RdRP activity in hTERT is essential for tumor formation. Here, we review the enzymatic function of RdRP in virus proliferation and tumor development, reminding us of how the study of the novel coronavirus has brought us to the unexpected intersection of cancer research and RNA virus research. Twit Text FOAVip RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID-19 ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=32805774 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32805774 #FOAvip English Wikipedia <ref>{{Cite pmid|32805774}}</ref> RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID-19 #MMPMID32805774 Machitani M; Yasukawa M; Nakashima J; Furuichi Y; Masutomi K Cancer Sci 2020[Nov]; 111 (11): 3976-3984 PMID32805774show ga A recent outbreak of coronavirus disease (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 has driven a global pandemic with catastrophic consequences. The rapid development of promising therapeutic strategies against COVID-19 is keenly anticipated. Family Coronaviridae comprises positive, single-stranded RNA viruses that use RNA-dependent RNA polymerase (RdRP) for viral replication and transcription. As the RdRP of viruses in this family and others plays a pivotal role in infection, it is a promising therapeutic target for developing antiviral agents against them. A critical genetic driver for many cancers is the catalytic subunit of telomerase: human telomerase reverse transcriptase (hTERT), identified initially as an RNA-dependent DNA polymerase. However, even though hTERT is a DNA polymerase, it has phylogenetic and structural similarities to viral RdRPs. Researchers worldwide, including the authors of this review, are engaged in developing therapeutic strategies targeting hTERT. We have published a series of papers reporting that hTERT has RdRP activity and that this RdRP activity in hTERT is essential for tumor formation. Here, we review the enzymatic function of RdRP in virus proliferation and tumor development, reminding us of how the study of the novel coronavirus has brought us to the unexpected intersection of cancer research and RNA virus research. |Animals[MESH] |COVID-19/enzymology/*virology[MESH] |Carcinogenesis/metabolism[MESH] |Humans[MESH] |RNA-Dependent RNA Polymerase/*metabolism[MESH] |SARS-CoV-2/*physiology[MESH] |Telomerase/*metabolism[MESH] |Viral Proteins/*metabolism[MESH]RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for(epmc).pdf DeepDyve Pubget Overpricing