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10.18632/aging.103770

http://scihub22266oqcxt.onion/10.18632/aging.103770
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32805722!7467395!32805722
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suck abstract from ncbi


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pmid32805722      Aging+(Albany+NY) 2020 ; 12 (15): 15670-15681
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  • Elevated Lactate Dehydrogenase (LDH) level as an independent risk factor for the severity and mortality of COVID-19 #MMPMID32805722
  • Li C; Ye J; Chen Q; Hu W; Wang L; Fan Y; Lu Z; Chen J; Chen Z; Chen S; Tong J; Xiao W; Mei J; Lu H
  • Aging (Albany NY) 2020[Aug]; 12 (15): 15670-15681 PMID32805722show ga
  • Early identification of severe patients with coronavirus disease 2019 (COVID-19) is very important for individual treatment. We included 203 patients with COVID-19 by propensity score matching in this retrospective, case-control study. The effects of serum lactate dehydrogenase (LDH) at admission on patients with COVID-19 were evaluated. We found that serum LDH levels had a 58.7% sensitivity and 82.0% specificity, based on a best cut-off of 277.00 U/L, for predicting severe COVID-19. And a cut-off of 359.50 U/L of the serum LDH levels resulted in a 93.8% sensitivity, 88.2% specificity for predicting death of COVID-19. Additionally, logistic regression analysis and Cox proportional hazards model respectively indicated that elevated LDH level was an independent risk factor for the severity (HR: 2.73, 95% CI: 1.25-5.97; P=0.012) and mortality (HR: 40.50, 95% CI: 3.65-449.28; P=0.003) of COVID-19. Therefore, elevated LDH level at admission is an independent risk factor for the severity and mortality of COVID-19. LDH can assist in the early evaluating of COVID-19. Clinicians should pay attention to the serum LDH level at admission for patients with COVID-19.
  • |*Coronavirus Infections/blood/diagnosis/epidemiology[MESH]
  • |*Pandemics[MESH]
  • |*Pneumonia, Viral/blood/diagnosis/epidemiology[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Case-Control Studies[MESH]
  • |China/epidemiology[MESH]
  • |Diagnostic Tests, Routine/methods[MESH]
  • |Early Diagnosis[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Lactate Dehydrogenases/*blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Patient Selection[MESH]
  • |Reproducibility of Results[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Assessment/*methods[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Sensitivity and Specificity[MESH]


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