Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1164/rccm.202005-2046OC http://scihub22266oqcxt.onion/10.1164/rccm.202005-2046OC 32805143!7605177!32805143     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Respir+Crit+Care+Med 2020 ; 202 (9): 1244-1252 Nephropedia Template TP {{tp|p=32805143|t=2020. Compliance Phenotypes in Early Acute Respiratory Distress Syndrome before the COVID-19 Pandemic |pdf=|usr=}}{{32805143}} gab.com Text Compliance Phenotypes in Early Acute Respiratory Distress Syndrome before the COVID-19 Pandemic JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=32805143 #FOAvip Rationale: A novel model of phenotypes based on set thresholds of respiratory system compliance (Crs) was recently postulated in context of coronavirus disease (COVID-19) acute respiratory distress syndrome (ARDS). In particular, the dissociation between the degree of hypoxemia and Crs was characterized as a distinct ARDS phenotype.Objectives: To determine whether such Crs-based phenotypes existed among patients with ARDS before the COVID-19 pandemic and to closely examine the Crs-mortality relationship.Methods: We undertook a secondary analysis of patients with ARDS, who were invasively ventilated on controlled modes and enrolled in a large, multinational, epidemiological study. We assessed Crs, degree of hypoxemia, and associated Crs-based phenotypic patterns with their characteristics and outcomes.Measurements and Main Results: Among 1,117 patients with ARDS who met inclusion criteria, the median Crs was 30 (interquartile range, 23-40) ml/cm H(2)O. One hundred thirty-six (12%) patients had preserved Crs (>/=50 ml/cm H(2)O; phenotype with low elastance ["phenotype L"]), and 827 (74%) patients had poor Crs (<40 ml/cm H(2)O; phenotype with high elastance ["phenotype H"]). Compared with those with phenotype L, patients with phenotype H were sicker and had more comorbidities and higher hospital mortality (32% vs. 45%; P < 0.05). A near complete dissociation between Pa(O(2))/Fi(O(2)) and Crs was observed. Of 136 patients with phenotype L, 58 (43%) had a Pa(O(2))/Fi(O(2)) < 150. In a multivariable-adjusted analysis, the Crs was independently associated with hospital mortality (adjusted odds ratio per ml/cm H(2)O increase, 0.988; 95% confidence interval, 0.979-0.996; P = 0.005).Conclusions: A wide range of Crs was observed in non-COVID-19 ARDS. Approximately one in eight patients had preserved Crs. Pa(O(2))/Fi(O(2)) and Crs were dissociated. Lower Crs was independently associated with higher mortality. The Crs-mortality relationship lacked a clear transition threshold. Twit Text FOAVip Compliance Phenotypes in Early Acute Respiratory Distress Syndrome before the COVID-19 Pandemic ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=32805143 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32805143 #FOAvip English Wikipedia <ref>{{Cite pmid|32805143}}</ref> Compliance Phenotypes in Early Acute Respiratory Distress Syndrome before the COVID-19 Pandemic #MMPMID32805143 Panwar R; Madotto F; Laffey JG; van Haren FMP Am J Respir Crit Care Med 2020[Nov]; 202 (9): 1244-1252 PMID32805143show ga Rationale: A novel model of phenotypes based on set thresholds of respiratory system compliance (Crs) was recently postulated in context of coronavirus disease (COVID-19) acute respiratory distress syndrome (ARDS). In particular, the dissociation between the degree of hypoxemia and Crs was characterized as a distinct ARDS phenotype.Objectives: To determine whether such Crs-based phenotypes existed among patients with ARDS before the COVID-19 pandemic and to closely examine the Crs-mortality relationship.Methods: We undertook a secondary analysis of patients with ARDS, who were invasively ventilated on controlled modes and enrolled in a large, multinational, epidemiological study. We assessed Crs, degree of hypoxemia, and associated Crs-based phenotypic patterns with their characteristics and outcomes.Measurements and Main Results: Among 1,117 patients with ARDS who met inclusion criteria, the median Crs was 30 (interquartile range, 23-40) ml/cm H(2)O. One hundred thirty-six (12%) patients had preserved Crs (>/=50 ml/cm H(2)O; phenotype with low elastance ["phenotype L"]), and 827 (74%) patients had poor Crs (<40 ml/cm H(2)O; phenotype with high elastance ["phenotype H"]). Compared with those with phenotype L, patients with phenotype H were sicker and had more comorbidities and higher hospital mortality (32% vs. 45%; P < 0.05). A near complete dissociation between Pa(O(2))/Fi(O(2)) and Crs was observed. Of 136 patients with phenotype L, 58 (43%) had a Pa(O(2))/Fi(O(2)) < 150. In a multivariable-adjusted analysis, the Crs was independently associated with hospital mortality (adjusted odds ratio per ml/cm H(2)O increase, 0.988; 95% confidence interval, 0.979-0.996; P = 0.005).Conclusions: A wide range of Crs was observed in non-COVID-19 ARDS. Approximately one in eight patients had preserved Crs. Pa(O(2))/Fi(O(2)) and Crs were dissociated. Lower Crs was independently associated with higher mortality. The Crs-mortality relationship lacked a clear transition threshold. |*Betacoronavirus[MESH] |*Pandemics[MESH] |COVID-19[MESH] |Coronavirus Infections/*epidemiology[MESH] |Female[MESH] |Follow-Up Studies[MESH] |Humans[MESH] |Intensive Care Units[MESH] |Lung Compliance/*physiology[MESH] |Male[MESH] |Middle Aged[MESH] |Pneumonia, Viral/*epidemiology[MESH] |Prospective Studies[MESH] |Respiratory Distress Syndrome/*physiopathology[MESH] |Respiratory Function Tests[MESH]Compliance Phenotypes in Early Acute Respiratory Distress Syndrome bef(epmc).pdf DeepDyve Pubget Overpricing