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10.1007/s00431-020-03766-6 http://scihub22266oqcxt.onion/10.1007/s00431-020-03766-6 32803422!7429125!32803422     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32803422&cmd=llinks): Failed to open stream: HTTP request failed! 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Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach |pdf=|usr=}}{{32803422}} gab.com Text Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach JO: Eur J Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=32803422 #FOAvip Initial reports on COVID-19 described children as largely spared from severe manifestations, with only 2-6% of children requiring intensive care treatment. However, since mid-April 2020, clusters of pediatric cases of severe systemic hyperinflammation and shock epidemiologically linked with COVID-19 have been reported. This condition was named as SARS-Cov-2-associated multisystem inflammatory syndrome in children and showed similarities to Kawasaki disease. Here, we present a narrative review of cases reported in literature and we discuss the clinical acute and follow-up management of these patients. Patients with SARS-Cov-2-associated multisystem inflammatory syndrome frequently presented with persistent fever, gastrointestinal symptoms, polymorphic rash, conjunctivitis, and mucosal changes. Elevated inflammatory markers and evidence of cytokine storm were frequently observed. A subset of these patients also presented with hypotension and shock (20-100%) from either acute myocardial dysfunction or systemic hyperinflammation/vasodilation. Coronary artery dilation or aneurysms have been described in 6-24%, and arrhythmias in 7-60%. Cardiac support, immunomodulation, and anticoagulation are the key aspects for the management of the acute phase. Long-term structured follow-up of these patients is required due to the unclear prognosis and risk of progression of cardiac manifestations.Conclusion: Multisystem inflammatory syndrome is a novel syndrome related to SARS-CoV-2 infection. Evidence is still scarce but rapidly emerging in the literature. Cardiac manifestations are frequent, including myocardial and coronary involvement, and need to be carefully identified and monitored over time. What is Known: * Multisystem inflammatory syndrome in children (MIS-C) has been described associated with SARS-CoV-2. What is New: * Patients with MIS-C often present with fever, gastrointestinal symptoms, and shock. * Cardiac involvement is found in a high proportion of these patients, including ventricular dysfunction, coronary artery dilation or aneurysm, and arrhythmias. * Management is based on expert consensus and includes cardiac support, immunomodulatory agents, and anticoagulation. * Long-term follow-up is required due to the unclear prognosis and risk of progression of cardiac manifestation. Twit Text FOAVip Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach ????Eur J Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=32803422 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32803422 #FOAvip English Wikipedia <ref>{{Cite pmid|32803422}}</ref> Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach #MMPMID32803422 Sperotto F; Friedman KG; Son MBF; VanderPluym CJ; Newburger JW; Dionne A Eur J Pediatr 2021[Feb]; 180 (2): 307-322 PMID32803422show ga Initial reports on COVID-19 described children as largely spared from severe manifestations, with only 2-6% of children requiring intensive care treatment. However, since mid-April 2020, clusters of pediatric cases of severe systemic hyperinflammation and shock epidemiologically linked with COVID-19 have been reported. This condition was named as SARS-Cov-2-associated multisystem inflammatory syndrome in children and showed similarities to Kawasaki disease. Here, we present a narrative review of cases reported in literature and we discuss the clinical acute and follow-up management of these patients. Patients with SARS-Cov-2-associated multisystem inflammatory syndrome frequently presented with persistent fever, gastrointestinal symptoms, polymorphic rash, conjunctivitis, and mucosal changes. Elevated inflammatory markers and evidence of cytokine storm were frequently observed. A subset of these patients also presented with hypotension and shock (20-100%) from either acute myocardial dysfunction or systemic hyperinflammation/vasodilation. Coronary artery dilation or aneurysms have been described in 6-24%, and arrhythmias in 7-60%. Cardiac support, immunomodulation, and anticoagulation are the key aspects for the management of the acute phase. Long-term structured follow-up of these patients is required due to the unclear prognosis and risk of progression of cardiac manifestations.Conclusion: Multisystem inflammatory syndrome is a novel syndrome related to SARS-CoV-2 infection. Evidence is still scarce but rapidly emerging in the literature. Cardiac manifestations are frequent, including myocardial and coronary involvement, and need to be carefully identified and monitored over time. What is Known: * Multisystem inflammatory syndrome in children (MIS-C) has been described associated with SARS-CoV-2. What is New: * Patients with MIS-C often present with fever, gastrointestinal symptoms, and shock. * Cardiac involvement is found in a high proportion of these patients, including ventricular dysfunction, coronary artery dilation or aneurysm, and arrhythmias. * Management is based on expert consensus and includes cardiac support, immunomodulatory agents, and anticoagulation. * Long-term follow-up is required due to the unclear prognosis and risk of progression of cardiac manifestation. |*SARS-CoV-2[MESH] |COVID-19/*complications[MESH] |Child[MESH] |Critical Care/statistics & numerical data[MESH] |Heart Diseases/*etiology[MESH] |Humans[MESH]Cardiac manifestations in SARS-CoV-2-associated multisystem inflammato(epmc).pdf DeepDyve Pubget Overpricing