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10.1155/2020/8624963

http://scihub22266oqcxt.onion/10.1155/2020/8624963
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suck abstract from ncbi


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pmid32802896      J+Immunol+Res 2020 ; 2020 (ä): 8624963
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  • The Application of Single-Cell RNA Sequencing in Vaccinology #MMPMID32802896
  • Noe A; Cargill TN; Nielsen CM; Russell AJC; Barnes E
  • J Immunol Res 2020[]; 2020 (ä): 8624963 PMID32802896show ga
  • Single-cell RNA sequencing allows highly detailed profiling of cellular immune responses from limited-volume samples, advancing prospects of a new era of systems immunology. The power of single-cell RNA sequencing offers various opportunities to decipher the immune response to infectious diseases and vaccines. Here, we describe the potential uses of single-cell RNA sequencing methods in prophylactic vaccine development, concentrating on infectious diseases including COVID-19. Using examples from several diseases, we review how single-cell RNA sequencing has been used to evaluate the immunological response to different vaccine platforms and regimens. By highlighting published and unpublished single-cell RNA sequencing studies relevant to vaccinology, we discuss some general considerations how the field could be enriched with the widespread adoption of this technology.
  • |*Single-Cell Analysis[MESH]
  • |Animals[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |COVID-19[MESH]
  • |Cell Line[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Coronavirus Infections/epidemiology/immunology/*prevention & control/virology[MESH]
  • |Disease Models, Animal[MESH]
  • |Drug Evaluation, Preclinical[MESH]
  • |Host-Pathogen Interactions/genetics/immunology[MESH]
  • |Humans[MESH]
  • |Immunity, Cellular/genetics[MESH]
  • |Immunity, Innate/genetics[MESH]
  • |Immunogenicity, Vaccine[MESH]
  • |Pandemics/*prevention & control[MESH]
  • |Pneumonia, Viral/epidemiology/immunology/*prevention & control/virology[MESH]
  • |RNA, Viral/isolation & purification[MESH]
  • |RNA-Seq/*methods[MESH]
  • |SARS-CoV-2[MESH]
  • |Vaccinology/*methods[MESH]


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