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10.2147/IDR.S259064

http://scihub22266oqcxt.onion/10.2147/IDR.S259064
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32801803!7406067!32801803
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suck abstract from ncbi


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pmid32801803      Infect+Drug+Resist 2020 ; 13 (ä): 2649-2655
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  • The Coronavirus Disease 2019 (COVID-19) in Children: A Study in an Iranian Children s Referral Hospital #MMPMID32801803
  • Mahmoudi S; Mehdizadeh M; Shervin Badv R; Navaeian A; Pourakbari B; Rostamyan M; Sharifzadeh Ekbatani M; Eshaghi H; Abdolsalehi MR; Alimadadi H; Movahedi Z; Mamishi S
  • Infect Drug Resist 2020[]; 13 (ä): 2649-2655 PMID32801803show ga
  • BACKGROUND: Despite the worldwide spread of the coronavirus disease 2019 (COVID-19), the epidemiological and clinical patterns of the COVID-19 infection remain largely unclear, particularly among children. In this study, we explored the epidemiological characteristics, clinical patterns, and laboratory and imaging findings of pediatric patients with COVID-19. MATERIALS AND METHODS: From March 7 to March 30, 2020, there were a total of 35 patients who had confirmed COVID-19 infection by laboratory virus nucleic acid test (RT-PCR) assay with throat swab samples or typical chest CT manifestation compatible with COVID-19, in addition to a history of close contact with suspected or confirmed SARS-CoV-2 in family members. Information recorded included demographic data, medical history, exposure history, underlying comorbidities, symptoms, signs, laboratory findings and radiologic assessments, severity of disease, treatment, and mortality. RESULTS: The median age of the patients was 7.5 years (IQR=4-11; range=4 months to 15 years). A total of 63% were male. Cough was present in 80% of the patients, followed by fever (77%), nausea or vomiting (29%), diarrhea (26%), shortness of breath (29%), headache (20%), and myalgia (14%). Lymphopenia was present in 43% of the patients, thrombocytopenia in 9%, neutopenia in 8%, and leucopenia in 26%. We reported severe pneumonia in 40% of the hospitalized patients and 18 (51%) had underlying diseases. Of 35 patients, 11 had positive RT-PCR results (31%). The chest CT images of 24 patients (69%) suggested COVID-19, while their RT-PCR assays from throat swab samples were negative. CONCLUSION: This study demonstrates different clinical findings of pediatrics compared to the previous reports of children. Since a high rate of false negative RT-PCR test was observed, early detection of children with COVID-19 infection by CT is conducive to reasonable management and early treatment.
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