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10.2147/IDR.S258639 http://scihub22266oqcxt.onion/10.2147/IDR.S258639 32801787!7383015!32801787     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Infect+Drug+Resist 2020 ; 13 (ä): 2485-2493 Nephropedia Template TP {{tp|p=32801787|t=2020. Role of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications for Therapy |pdf=|usr=}}{{32801787}} gab.com Text Role of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications for Therapy JO: Infect Drug Resist http://www.kidney.de/pget.php?&tw=1&pmid=32801787 #FOAvip Emerging studies from SARS-CoV-2-infected patients indicate a preponderant role of monocytes/macrophages in the pathogenesis of this viral infection, in a similar way to that previously observed in other coronavirus outbreaks (SARS and MERS). The clinical presentation of severe patients resembles viral-associated hemophagocytic syndrome, a rare condition previously seen during lethal influenza pandemics and during previous SARS and MERS coronavirus outbreaks. SARS-CoV-2 infection triggers an over-exuberant inflammatory response due to the development of a cytokine storm and the depletion of the adaptative immune compartment, which may prelude sepsis in many cases. The present review summarizes past evidence on the role of monocytes/macrophages in previous coronavirus outbreaks and the emerging knowledge on their role in COVID-19 pathogenesis. Treatment strategies incorporating the blockade of migration and differentiation of monocyte-macrophage, such as granulocyte macrophage-colony stimulating factor inhibitors, might enhance the promising results seen so far with selective cytokine blockade. Twit Text FOAVip Role of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications for Therapy ????Infect Drug Resist http://www.kidney.de/pget.php?&tw=1&pmid=32801787 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32801787 #FOAvip English Wikipedia <ref>{{Cite pmid|32801787}}</ref> Role of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications for Therapy #MMPMID32801787 Gomez-Rial J; Rivero-Calle I; Salas A; Martinon-Torres F Infect Drug Resist 2020[]; 13 (ä): 2485-2493 PMID32801787show ga Emerging studies from SARS-CoV-2-infected patients indicate a preponderant role of monocytes/macrophages in the pathogenesis of this viral infection, in a similar way to that previously observed in other coronavirus outbreaks (SARS and MERS). The clinical presentation of severe patients resembles viral-associated hemophagocytic syndrome, a rare condition previously seen during lethal influenza pandemics and during previous SARS and MERS coronavirus outbreaks. SARS-CoV-2 infection triggers an over-exuberant inflammatory response due to the development of a cytokine storm and the depletion of the adaptative immune compartment, which may prelude sepsis in many cases. The present review summarizes past evidence on the role of monocytes/macrophages in previous coronavirus outbreaks and the emerging knowledge on their role in COVID-19 pathogenesis. Treatment strategies incorporating the blockade of migration and differentiation of monocyte-macrophage, such as granulocyte macrophage-colony stimulating factor inhibitors, might enhance the promising results seen so far with selective cytokine blockade. äRole of Monocytes/Macrophages in Covid-19 Pathogenesis: Implications f(epmc).pdf DeepDyve Pubget Overpricing