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10.2147/DDDT.S259058

http://scihub22266oqcxt.onion/10.2147/DDDT.S259058
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32801640!7396737!32801640
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suck abstract from ncbi


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pmid32801640      Drug+Des+Devel+Ther 2020 ; 14 (ä): 3001-3013
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  • Antiviral Agent Therapy Optimization in Special Populations of COVID-19 Patients #MMPMID32801640
  • Li L; Wang X; Wang R; Hu Y; Jiang S; Lu X
  • Drug Des Devel Ther 2020[]; 14 (ä): 3001-3013 PMID32801640show ga
  • Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now a global outbreak of disease. The antiviral treatment acts as one of the most important means of SARS-CoV-2 infection. Alteration of physiological characteristics in special populations may lead to the change in drug pharmacokinetics, which may result in treatment failure or increased adverse drug reactions. Some potential drugs have shown antiviral effects on SARS-CoV-2 infections, such as chloroquine, hydroxychloroquine, favipiravir, lopinavir/ritonavir, arbidol, interferon alpha, and remedsivir. Here, we reviewed the literature on clinical effects in COVID-19 patients of these antiviral agents and provided the potential antiviral agent options for pregnant women, elderly patients, liver or renal dysfunction patients, and severe or critically ill patients receiving renal replacement therapy or ECMO after SARS-CoV-2 infection.
  • |Aged[MESH]
  • |Antiviral Agents/adverse effects/pharmacokinetics/*pharmacology[MESH]
  • |Betacoronavirus/drug effects/isolation & purification[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/*drug therapy/epidemiology/virology[MESH]
  • |Critical Illness[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Kidney Diseases/complications[MESH]
  • |Liver Diseases/complications[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/epidemiology/virology[MESH]
  • |Pregnancy[MESH]


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