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10.1016/j.drudis.2020.08.002

http://scihub22266oqcxt.onion/10.1016/j.drudis.2020.08.002
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suck abstract from ncbi


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pmid32801052      Drug+Discov+Today 2020 ; 25 (10): 1822-1838
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  • Derivatization and combination therapy of current COVID-19 therapeutic agents: a review of mechanistic pathways, adverse effects, and binding sites #MMPMID32801052
  • El Kantar S; Nehmeh B; Saad P; Mitri G; Estephan C; Mroueh M; Akoury E; Taleb RI
  • Drug Discov Today 2020[Oct]; 25 (10): 1822-1838 PMID32801052show ga
  • Current treatment of patients with coronavirus 2019 (COVID-19) involves repurposed drugs that inhibit viral infection by either binding to their respective targets or via modulating cellular signal transduction. However, there is still a great deal of efficacy enhancement through combination therapy and derivatization. Combination therapy should involve agents with significant activity and different mechanisms of action. The structural map of the interaction between a drug and its target protein will help guide drug discovery for devising safe and effective ways to treat COVID-19. Herein, we report numerous synthetic designs based on enhanced affinity to the viral carbohydrate-rich protein spikes and protein-binding sites of COVID-19.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Drug Repositioning[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/adverse effects/*therapeutic use[MESH]
  • |Binding Sites[MESH]
  • |COVID-19/metabolism/mortality/virology[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Evidence-Based Medicine[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Ligands[MESH]
  • |Molecular Targeted Therapy[MESH]
  • |SARS-CoV-2/*drug effects/metabolism/pathogenicity[MESH]
  • |Signal Transduction/*drug effects[MESH]


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