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10.1186/s12872-020-01658-z

http://scihub22266oqcxt.onion/10.1186/s12872-020-01658-z
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suck abstract from ncbi


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pmid32799852      BMC+Cardiovasc+Disord 2020 ; 20 (1): 373
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  • Implications of AB0 blood group in hypertensive patients with covid-19 #MMPMID32799852
  • Sardu C; Marfella R; Maggi P; Messina V; Cirillo P; Codella V; Gambardella J; Sardu A; Gatta G; Santulli G; Paolisso G
  • BMC Cardiovasc Disord 2020[Aug]; 20 (1): 373 PMID32799852show ga
  • BACKGROUND: Hypertension is the most frequent co-morbidity in patients with covid-19 infection, and we might speculate that a specific blood group could play a key role in the clinical outcome of hypertensive patients with covid-19. METHODS: In this prospective study, we compared 0 vs. non-0 blood group in hypertensive patients with covid-19 infection. In these patients, we evaluated inflammatory and thrombotic status, cardiac injury, and death events. RESULTS: Patients in non-0 (n = 92) vs. 0 blood group (n = 72) had significantly different values of activated pro-thrombin time, D-dimer, and thrombotic indexes as Von Willebrand factor and Factor VIII (p < 0.05). Furthermore, patients in non-0 vs. 0 blood group had higher rate of cardiac injury (10 (13.9%) vs. 27 (29.3%)) and death, (6 (8.3%) vs. 18 (19.6%)), (p < 0.05). At the multivariate analysis, Interleukin-6 (1.118, CI 95% 1.067-1.171) and non-0 blood group (2.574, CI 95% 1.207-5.490) were independent predictors of cardiac injury in hypertensive patients with covid-19. D-dimer (1.082, CI 95% 1.027-1.140), Interleukin-6 (1.216, CI 95% 1.082-1.367) and non-0 blood group (3.706, CI 95% 1.223-11.235) were independent predictors of deaths events in hypertensive patients with covid-19. CONCLUSIONS: Taken together, our data indicate that non-0 covid-19 hypertensive patients have significantly higher values of pro-thrombotic indexes, as well as higher rate of cardiac injury and deaths compared to 0 patients. Moreover, AB0 blood type influences worse prognosis in hypertensive patients with covid-19 infection.
  • |*ABO Blood-Group System[MESH]
  • |*Blood Pressure[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Betacoronavirus/*pathogenicity[MESH]
  • |Biomarkers/blood[MESH]
  • |Blood Coagulation[MESH]
  • |Blood Coagulation Factors/analysis[MESH]
  • |COVID-19[MESH]
  • |Case-Control Studies[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/*blood/diagnosis/epidemiology/virology[MESH]
  • |Female[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Hypertension/*blood/diagnosis/epidemiology/physiopathology[MESH]
  • |Inflammation Mediators/blood[MESH]
  • |Italy/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/diagnosis/epidemiology/virology[MESH]
  • |Prospective Studies[MESH]
  • |Risk Factors[MESH]


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