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10.1111/cts.12862 http://scihub22266oqcxt.onion/10.1111/cts.12862 32799423!7461457!32799423     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Transl+Sci 2020 ; 13 (6): 1048-1054 Nephropedia Template TP {{tp|p=32799423|t=2020. Effect of Common Medications on the Expression of SARS-CoV-2 Entry Receptors in Kidney Tissue |pdf=|usr=}}{{32799423}} gab.com Text Effect of Common Medications on the Expression of SARS-CoV-2 Entry Receptors in Kidney Tissue JO: Clin Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=32799423 #FOAvip Besides the respiratory system, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection was shown to affect other essential organs such as the kidneys. Early kidney involvement during the course of infection was associated with worse outcomes, which could be attributed to the direct SARS-CoV-2 infection of kidney cells. In this study, the effect of commonly used medications on the expression of SARS-CoV-2 receptor, angiotensin-converting enzyme (ACE)2, and TMPRSS2 protein in kidney tissues was evaluated. This was done by in silico analyses of publicly available transcriptomic databases of kidney tissues of rats treated with multiple doses of commonly used medications. Of 59 tested medications, 56% modified ACE2 expression, whereas 24% modified TMPRSS2 expression. ACE2 was increased with only a few of the tested medication groups, namely the renin-angiotensin inhibitors, such as enalapril, antibacterial agents, such as nitrofurantoin, and the proton pump inhibitor, omeprazole. The majority of the other medications decreased ACE2 expression to variable degrees with allopurinol and cisplatin causing the most noticeable downregulation. The expression level of TMPRSS2 was increased with a number of medications, such as diclofenac, furosemide, and dexamethasone, whereas other medications, such as allopurinol, suppressed the expression of this gene. The prolonged exposure to combinations of these medications could regulate the expression of ACE2 and TMPRSS2 in a way that may affect kidney susceptibility to SARS-CoV-2 infection. Data presented here suggest that we should be vigilant about the potential effects of commonly used medications on kidney tissue expression of ACE2 and TMPRSS2. Twit Text FOAVip Effect of Common Medications on the Expression of SARS-CoV-2 Entry Receptors in Kidney Tissue ????Clin Transl Sci http://www.kidney.de/pget.php?&tw=1&pmid=32799423 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32799423 #FOAvip English Wikipedia <ref>{{Cite pmid|32799423}}</ref> Effect of Common Medications on the Expression of SARS-CoV-2 Entry Receptors in Kidney Tissue #MMPMID32799423 Saheb Sharif-Askari N; Saheb Sharif-Askari F; Alabed M; Tayoun AA; Loney T; Uddin M; Senok A; Al Heialy S; Hamoudi R; Kashour T; Alsheikh-Ali A; Hamid Q; Halwani R Clin Transl Sci 2020[Nov]; 13 (6): 1048-1054 PMID32799423show ga Besides the respiratory system, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection was shown to affect other essential organs such as the kidneys. Early kidney involvement during the course of infection was associated with worse outcomes, which could be attributed to the direct SARS-CoV-2 infection of kidney cells. In this study, the effect of commonly used medications on the expression of SARS-CoV-2 receptor, angiotensin-converting enzyme (ACE)2, and TMPRSS2 protein in kidney tissues was evaluated. This was done by in silico analyses of publicly available transcriptomic databases of kidney tissues of rats treated with multiple doses of commonly used medications. Of 59 tested medications, 56% modified ACE2 expression, whereas 24% modified TMPRSS2 expression. ACE2 was increased with only a few of the tested medication groups, namely the renin-angiotensin inhibitors, such as enalapril, antibacterial agents, such as nitrofurantoin, and the proton pump inhibitor, omeprazole. The majority of the other medications decreased ACE2 expression to variable degrees with allopurinol and cisplatin causing the most noticeable downregulation. The expression level of TMPRSS2 was increased with a number of medications, such as diclofenac, furosemide, and dexamethasone, whereas other medications, such as allopurinol, suppressed the expression of this gene. The prolonged exposure to combinations of these medications could regulate the expression of ACE2 and TMPRSS2 in a way that may affect kidney susceptibility to SARS-CoV-2 infection. Data presented here suggest that we should be vigilant about the potential effects of commonly used medications on kidney tissue expression of ACE2 and TMPRSS2. |*SARS-CoV-2[MESH] |Angiotensin-Converting Enzyme 2/*genetics[MESH] |Animals[MESH] |COVID-19/*complications[MESH] |Gene Expression Regulation/drug effects[MESH] |Kidney/*metabolism[MESH] |Rats[MESH] |Receptors, Coronavirus/*genetics[MESH]Effect of Common Medications on the Expression of SARS-CoV-2 Entry Rec(epmc).pdf DeepDyve Pubget Overpricing