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10.1016/j.ejmech.2020.112702 http://scihub22266oqcxt.onion/10.1016/j.ejmech.2020.112702 32798789!7395831!32798789     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32798789&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Eur+J+Med+Chem 2020 ; 206 (?): 112702 Nephropedia Template TP {{tp|p=32798789|t=2020. Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds |pdf=|usr=}}{{32798789}} gab.com Text Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds JO: Eur J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=32798789 #FOAvip SARS-CoV-2 3C-like protease is the main protease of SARS-CoV-2 and has been considered as one of the key targets for drug discovery against COVID-19. We identified several N-substituted isatin compounds as potent SARS-CoV-2 3C-like protease inhibitors. The three most potent compounds inhibit SARS-CoV-2 3C-like protease with IC(50)'s of 45 nM, 47 nM and 53 nM, respectively. Our study indicates that N-substituted isatin compounds have the potential to be developed as broad-spectrum anti-coronavirus drugs. Twit Text FOAVip Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds ????Eur J Med Chem http://www.kidney.de/pget.php?&tw=1&pmid=32798789 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32798789 #FOAvip English Wikipedia <ref>{{Cite pmid|32798789}}</ref> Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substituted isatin compounds #MMPMID32798789 Liu P; Liu H; Sun Q; Liang H; Li C; Deng X; Liu Y; Lai L Eur J Med Chem 2020[Nov]; 206 (?): 112702 PMID32798789show ga SARS-CoV-2 3C-like protease is the main protease of SARS-CoV-2 and has been considered as one of the key targets for drug discovery against COVID-19. We identified several N-substituted isatin compounds as potent SARS-CoV-2 3C-like protease inhibitors. The three most potent compounds inhibit SARS-CoV-2 3C-like protease with IC(50)'s of 45 nM, 47 nM and 53 nM, respectively. Our study indicates that N-substituted isatin compounds have the potential to be developed as broad-spectrum anti-coronavirus drugs. |Antiviral Agents/pharmacology/*therapeutic use[MESH] |Betacoronavirus/*drug effects[MESH] |Coronavirus 3C Proteases[MESH] |Cysteine Endopeptidases[MESH] |Humans[MESH] |Isatin/analogs & derivatives/chemical synthesis/*therapeutic use[MESH] |Models, Molecular[MESH] |Molecular Docking Simulation[MESH] |Protease Inhibitors/chemical synthesis/pharmacology/*therapeutic use[MESH] |SARS-CoV-2[MESH] |Structure-Activity Relationship[MESH]Potent inhibitors of SARS-CoV-2 3C-like protease derived from N-substi(epmc).pdf DeepDyve Pubget Overpricing