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10.1016/j.phymed.2020.153297

http://scihub22266oqcxt.onion/10.1016/j.phymed.2020.153297
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32798019!7405862!32798019
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suck abstract from ncbi

pmid32798019      Phytomedicine 2021 ; 85 (?): 153297
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  • Therapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanism #MMPMID32798019
  • Zhang JL; Li WX; Li Y; Wong MS; Wang YJ; Zhang Y
  • Phytomedicine 2021[May]; 85 (?): 153297 PMID32798019show ga
  • BACKGROUND: Coronavirus disease-2019 (COVID-19) caused by infection with severe acute respiratory coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout China and in other countries since the end of 2019. The World Health Organization (WHO) has declared that the epidemic is a public health emergency of international concerns. The timely and appropriate measures for treating COVID-19 in China, which are inseparable from the contribution of traditional Chinese medicine (TCM), have won much praise of the world. PURPOSE: This review aimed to summarize and discuss the essential role of TCM in protecting tissues from injuries associated with COVID-19, and accordingly to clarify the possible action mechanisms of TCM from the perspectives of anti-inflammatory, antioxidant and anti-apoptotic effects. METHODS: Electronic databases such as Pubmed, ResearchGate, Science Direct, Web of Science, medRixv and Wiley were used to search scientific literatures. RESULTS: The present review found that traditional Chinese herbs commonly used for the clinical treatment of organ damages caused by COVID-19, such as Scutellaria baicalensis, Salvia miltiorrhizaSalvia miltiorrhiza, and ginseng, could act on multiple signaling pathways involved in inflammation, oxidative stress and apoptosis. CONCLUSION: TCM could protect COVID-19 patients from tissue injuries, a protection that might be, at least partially, attributed to the anti-inflammatory, antioxidant and anti-apoptotic effects of the TCM under investigation. This review provides evidence and support for clinical treatment and novel drug research using TCM.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Medicine, Chinese Traditional[MESH]
  • |Anti-Inflammatory Agents/therapeutic use[MESH]
  • |Antioxidants/therapeutic use[MESH]
  • |Apoptosis/drug effects[MESH]
  • |China[MESH]
  • |Drugs, Chinese Herbal/*therapeutic use[MESH]
  • |Humans[MESH]
  • |Inflammation[MESH]
  • |Oxidative Stress[MESH]


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