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10.1038/s41392-020-00263-y http://scihub22266oqcxt.onion/10.1038/s41392-020-00263-y 32796814!7426596!32796814     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Signal+Transduct+Target+Ther 2020 ; 5 (1): 156 Nephropedia Template TP {{tp|p=32796814|t=2020. Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals |pdf=|usr=}}{{32796814}} gab.com Text Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals JO: Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=32796814 #FOAvip The global Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has affected more than eight million people. There is an urgent need to investigate how the adaptive immunity is established in COVID-19 patients. In this study, we profiled adaptive immune cells of PBMCs from recovered COVID-19 patients with varying disease severity using single-cell RNA and TCR/BCR V(D)J sequencing. The sequencing data revealed SARS-CoV-2-specific shuffling of adaptive immune repertories and COVID-19-induced remodeling of peripheral lymphocytes. Characterization of variations in the peripheral T and B cells from the COVID-19 patients revealed a positive correlation of humoral immune response and T-cell immune memory with disease severity. Sequencing and functional data revealed SARS-CoV-2-specific T-cell immune memory in the convalescent COVID-19 patients. Furthermore, we also identified novel antigens that are responsive in the convalescent patients. Altogether, our study reveals adaptive immune repertories underlying pathogenesis and recovery in severe versus mild COVID-19 patients, providing valuable information for potential vaccine and therapeutic development against SARS-CoV-2 infection. Twit Text FOAVip Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals ????Signal Transduct Target Ther http://www.kidney.de/pget.php?&tw=1&pmid=32796814 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32796814 #FOAvip English Wikipedia <ref>{{Cite pmid|32796814}}</ref> Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals #MMPMID32796814 Zhang F; Gan R; Zhen Z; Hu X; Li X; Zhou F; Liu Y; Chen C; Xie S; Zhang B; Wu X; Huang Z Signal Transduct Target Ther 2020[Aug]; 5 (1): 156 PMID32796814show ga The global Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has affected more than eight million people. There is an urgent need to investigate how the adaptive immunity is established in COVID-19 patients. In this study, we profiled adaptive immune cells of PBMCs from recovered COVID-19 patients with varying disease severity using single-cell RNA and TCR/BCR V(D)J sequencing. The sequencing data revealed SARS-CoV-2-specific shuffling of adaptive immune repertories and COVID-19-induced remodeling of peripheral lymphocytes. Characterization of variations in the peripheral T and B cells from the COVID-19 patients revealed a positive correlation of humoral immune response and T-cell immune memory with disease severity. Sequencing and functional data revealed SARS-CoV-2-specific T-cell immune memory in the convalescent COVID-19 patients. Furthermore, we also identified novel antigens that are responsive in the convalescent patients. Altogether, our study reveals adaptive immune repertories underlying pathogenesis and recovery in severe versus mild COVID-19 patients, providing valuable information for potential vaccine and therapeutic development against SARS-CoV-2 infection. |*Immunity, Cellular[MESH] |*Immunity, Humoral[MESH] |Antigens, Viral/genetics/immunology[MESH] |B-Lymphocytes/classification/*immunology/virology[MESH] |Betacoronavirus/immunology/*pathogenicity[MESH] |COVID-19[MESH] |Case-Control Studies[MESH] |China[MESH] |Convalescence[MESH] |Coronavirus Infections/genetics/*immunology/pathology/virology[MESH] |Disease Progression[MESH] |Gene Expression[MESH] |High-Throughput Nucleotide Sequencing[MESH] |Host-Pathogen Interactions/immunology[MESH] |Humans[MESH] |Immunologic Memory[MESH] |Pandemics[MESH] |Pneumonia, Viral/genetics/*immunology/pathology/virology[MESH] |Receptors, Antigen, B-Cell/classification/genetics/immunology[MESH] |Receptors, Antigen, T-Cell/classification/genetics/immunology[MESH] |SARS-CoV-2[MESH] |Severity of Illness Index[MESH] |Single-Cell Analysis[MESH]Adaptive immune responses to SARS-CoV-2 infection in severe versus mil(epmc).pdf DeepDyve Pubget Overpricing