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10.1136/thoraxjnl-2020-215732

http://scihub22266oqcxt.onion/10.1136/thoraxjnl-2020-215732
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32796119!7430184!32796119
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suck abstract from ncbi


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pmid32796119      Thorax 2020 ; 75 (12): 1082-1088
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  • Clinical and laboratory evaluation of SARS-CoV-2 lateral flow assays for use in a national COVID-19 seroprevalence survey #MMPMID32796119
  • Flower B; Brown JC; Simmons B; Moshe M; Frise R; Penn R; Kugathasan R; Petersen C; Daunt A; Ashby D; Riley S; Atchison CJ; Taylor GP; Satkunarajah S; Naar L; Klaber R; Badhan A; Rosadas C; Khan M; Fernandez N; Sureda-Vives M; Cheeseman HM; O'Hara J; Fontana G; Pallett SJC; Rayment M; Jones R; Moore LSP; McClure MO; Cherepanov P; Tedder R; Ashrafian H; Shattock R; Ward H; Darzi A; Elliot P; Barclay WS; Cooke GS
  • Thorax 2020[Dec]; 75 (12): 1082-1088 PMID32796119show ga
  • BACKGROUND: Accurate antibody tests are essential to monitor the SARS-CoV-2 pandemic. Lateral flow immunoassays (LFIAs) can deliver testing at scale. However, reported performance varies, and sensitivity analyses have generally been conducted on serum from hospitalised patients. For use in community testing, evaluation of finger-prick self-tests, in non-hospitalised individuals, is required. METHODS: Sensitivity analysis was conducted on 276 non-hospitalised participants. All had tested positive for SARS-CoV-2 by reverse transcription PCR and were >/=21 days from symptom onset. In phase I, we evaluated five LFIAs in clinic (with finger prick) and laboratory (with blood and sera) in comparison to (1) PCR-confirmed infection and (2) presence of SARS-CoV-2 antibodies on two 'in-house' ELISAs. Specificity analysis was performed on 500 prepandemic sera. In phase II, six additional LFIAs were assessed with serum. FINDINGS: 95% (95% CI 92.2% to 97.3%) of the infected cohort had detectable antibodies on at least one ELISA. LFIA sensitivity was variable, but significantly inferior to ELISA in 8 out of 11 assessed. Of LFIAs assessed in both clinic and laboratory, finger-prick self-test sensitivity varied from 21% to 92% versus PCR-confirmed cases and from 22% to 96% versus composite ELISA positives. Concordance between finger-prick and serum testing was at best moderate (kappa 0.56) and, at worst, slight (kappa 0.13). All LFIAs had high specificity (97.2%-99.8%). INTERPRETATION: LFIA sensitivity and sample concordance is variable, highlighting the importance of evaluations in setting of intended use. This rigorous approach to LFIA evaluation identified a test with high specificity (98.6% (95%CI 97.1% to 99.4%)), moderate sensitivity (84.4% with finger prick (95% CI 70.5% to 93.5%)) and moderate concordance, suitable for seroprevalence surveys.
  • |*Pandemics[MESH]
  • |Adult[MESH]
  • |Antibodies, Viral/*analysis[MESH]
  • |COVID-19/*diagnosis/epidemiology/virology[MESH]
  • |DNA, Viral/analysis[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Humans[MESH]
  • |Immunoassay/*methods[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Reproducibility of Results[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2/genetics/*immunology[MESH]


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