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10.1016/j.mehy.2020.110167

http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.110167
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suck abstract from ncbi


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pmid32795835      Med+Hypotheses 2020 ; 144 (ä): 110167
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  • Is there a role for insulin-like growth factor inhibition in the treatment of COVID-19-related adult respiratory distress syndrome? #MMPMID32795835
  • Winn BJ
  • Med Hypotheses 2020[Nov]; 144 (ä): 110167 PMID32795835show ga
  • Adult respiratory distress syndrome (ARDS) is the leading cause of death associated with SARS-CoV-2 infection and COVID-19. IGF-1 has been implicated in ARDS, yet its role in relation to COVID-19-related lung injury has not been investigated. We hypothesize that blockage of the IGF-1 receptor (IGF-1R) mitigates lung injury and decreases the risk of death in patients COVID-19-related ARDS. Patients with fibroproliferative ARDS have been shown to have increased IGF-1 and IGF-1R staining in lung tissue specimens. Rising levels of IGF-1 in bronchioalveolar fluid (BAL) and increased IGF-1 mRNA expression in lung tissues (but declining serum IGF-1 levels) have been found in late stage ARDS compared with early lung injury. Blockage of IGF-1R decreases lung tissue damage and increases survival in bleomycin-induced as well as H1N1 influenza-related lung injury in animal models. Teprotumumab is a monoclonal antibody directed against the IGF-1R that was FDA-approved in 2020 for the treatment of Graves' orbitopathy. In order to determine if teprotumumab may reduce lung injury and death related to ARDS in the setting of COVID-19, preliminary clinical data is needed. IGF-1 levels in serum and BAL fluid must be measured in patients with COVID-19-related ARDS. Histopathology from lung samples from patients with COVID-19-related ARDS must be examined for increased expression of the IGF-1R. Once these are ascertained, and if the data support IGF-1 involvement, a randomized, placebo-controlled phase 2A trial of teprotumumab therapy in the setting of COVID-19-related ARDS and non-COVID-19-related ARDS designed to generate initial data on short-term efficacy, safety, dosing and administration should be performed.
  • |*COVID-19 Drug Treatment[MESH]
  • |Animals[MESH]
  • |Antibodies, Monoclonal, Humanized/pharmacology[MESH]
  • |Bleomycin/pharmacology[MESH]
  • |Bronchoalveolar Lavage Fluid[MESH]
  • |Humans[MESH]
  • |Influenza A Virus, H1N1 Subtype[MESH]
  • |Insulin-Like Growth Factor I/metabolism[MESH]
  • |Mice[MESH]
  • |Models, Theoretical[MESH]
  • |Receptor, IGF Type 1/metabolism[MESH]
  • |Respiratory Distress Syndrome/*drug therapy/virology[MESH]
  • |Risk[MESH]
  • |Somatomedins/*antagonists & inhibitors[MESH]


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