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10.1016/j.mehy.2020.109935

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suck abstract from ncbi


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pmid32795834      Med+Hypotheses 2020 ; 144 (ä): 109935
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  • IL-17A and TNF-alpha as potential biomarkers for acute respiratory distress syndrome and mortality in patients with obesity and COVID-19 #MMPMID32795834
  • Leija-Martinez JJ; Huang F; Del-Rio-Navarro BE; Sanchez-Munoz F; Munoz-Hernandez O; Giacoman-Martinez A; Hall-Mondragon MS; Espinosa-Velazquez D
  • Med Hypotheses 2020[Nov]; 144 (ä): 109935 PMID32795834show ga
  • Coronavirus disease 2019 (COVID-19) was declared a pandemic and international health emergency by the World Health Organization. Patients with obesity with COVID-19 are 7 times more likely to need invasive mechanical ventilation than are patients without obesity (OR 7.36; 95% CI: 1.63-33.14, p = 0.021). Acute respiratory distress syndrome (ARDS) is one of the main causes of death related to COVID-19 and is triggered by a cytokine storm that damages the respiratory epithelium. Interleukins that cause the chronic low-grade inflammatory state of obesity, such as interleukin (IL)-1beta, IL-6, monocyte chemoattractant peptide (MCP)-1, and, in particular, IL-17A and tumour necrosis factor alpha (TNF-alpha), also play very important roles in lung damage in ARDS. Therefore, obesity is associated with an immune state favourable to a cytokine storm. Our hypothesis is that serum concentrations of TNF-alpha and IL-17A are more elevated in patients with obesity and COVID-19, and consequently, they have a greater probability of developing ARDS and death. The immunobiology of IL-17A and TNF-alpha opens a new fascinating field of research for COVID-19.
  • |Biomarkers/blood[MESH]
  • |COVID-19/*complications/immunology/mortality[MESH]
  • |Cytokine Release Syndrome/etiology/immunology/mortality[MESH]
  • |Humans[MESH]
  • |Interleukin-17/*blood[MESH]
  • |Models, Immunological[MESH]
  • |Obesity/*complications/immunology[MESH]
  • |Pandemics[MESH]
  • |Respiratory Distress Syndrome/*etiology/immunology/mortality[MESH]
  • |Respiratory Mucosa/immunology/injuries[MESH]
  • |Risk Factors[MESH]


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