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10.1016/j.diagmicrobio.2020.115141 http://scihub22266oqcxt.onion/10.1016/j.diagmicrobio.2020.115141 32795776!7366972!32795776     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diagn+Microbiol+Infect+Dis 2020 ; 98 (3): 115141 Nephropedia Template TP {{tp|p=32795776|t=2020. False-positive SARS-CoV-2 serology in 3 children with Kawasaki disease |pdf=|usr=}}{{32795776}} gab.com Text False-positive SARS-CoV-2 serology in 3 children with Kawasaki disease JO: Diagn Microbiol Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32795776 #FOAvip BACKGROUND: Kawasaki disease (KD) is an acute febrile and eruptive disease with systemic vasculitis predominantly affecting young East Asian children. Recent reports showed that children with KD-like disease from KD low prevalence regions had positive SARS-CoV-2 serology despite a negative SARS-CoV-2 polymerase chain reaction (PCR) in respiratory samples. OBJECTIVES: To describe 3 pediatric Kawasaki Disease patients with false positive SARS-CoV-2 serology. STUDY DESIGN: We retrospectively recruited children with KD diagnosed during the COVID-19 outbreak in Hong Kong. Clinical characteristics and laboratory test results including SARS-CoV-2 PCR results were retrieved. We performed a microparticle-based immunoassay for the detection of IgG against nucleoprotein (NP) and spike protein receptor binding domain (RBD), and a microneutralization assay for the detection of neutralizing antibodies. RESULTS: Three Chinese children with typical KD were identified. They had no epidemiological links with COVID-19 patients and tested negative for SARS-CoV-2 NPA PCR. They were treated with IVIG and aspirin, and were discharged without complications. Subsequently 2 of them were tested positive against anti-RBD and anti-NP antibodies and 1 was tested positive against anti- RBD antibodies. However, microneutralization assay showed that neutralizing antibodies were absent, suggesting a false-positive IgG result. CONCLUSION: Detection of neutralizing antibodies is recommended to confirm previous SARS-CoV-2 infection in IgG-positive but PCR-negative patients. Twit Text FOAVip False-positive SARS-CoV-2 serology in 3 children with Kawasaki disease ????Diagn Microbiol Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=32795776 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32795776 #FOAvip English Wikipedia <ref>{{Cite pmid|32795776}}</ref> False-positive SARS-CoV-2 serology in 3 children with Kawasaki disease #MMPMID32795776 To KK; Chua GT; Kwok KL; Wong JS; Au DCY; Lam YY; Wong WH; Ho MH; Chan GC; Chui CS; Li X; Tung KT; Wong RS; Tso WW; Wong IC; Wong CS; Fong CH; Chan KH; Yuen KY; Ip P; Kwan MY Diagn Microbiol Infect Dis 2020[Nov]; 98 (3): 115141 PMID32795776show ga BACKGROUND: Kawasaki disease (KD) is an acute febrile and eruptive disease with systemic vasculitis predominantly affecting young East Asian children. Recent reports showed that children with KD-like disease from KD low prevalence regions had positive SARS-CoV-2 serology despite a negative SARS-CoV-2 polymerase chain reaction (PCR) in respiratory samples. OBJECTIVES: To describe 3 pediatric Kawasaki Disease patients with false positive SARS-CoV-2 serology. STUDY DESIGN: We retrospectively recruited children with KD diagnosed during the COVID-19 outbreak in Hong Kong. Clinical characteristics and laboratory test results including SARS-CoV-2 PCR results were retrieved. We performed a microparticle-based immunoassay for the detection of IgG against nucleoprotein (NP) and spike protein receptor binding domain (RBD), and a microneutralization assay for the detection of neutralizing antibodies. RESULTS: Three Chinese children with typical KD were identified. They had no epidemiological links with COVID-19 patients and tested negative for SARS-CoV-2 NPA PCR. They were treated with IVIG and aspirin, and were discharged without complications. Subsequently 2 of them were tested positive against anti-RBD and anti-NP antibodies and 1 was tested positive against anti- RBD antibodies. However, microneutralization assay showed that neutralizing antibodies were absent, suggesting a false-positive IgG result. CONCLUSION: Detection of neutralizing antibodies is recommended to confirm previous SARS-CoV-2 infection in IgG-positive but PCR-negative patients. |Antibodies, Neutralizing/*blood[MESH] |Antibodies, Viral/*blood[MESH] |Betacoronavirus/immunology[MESH] |COVID-19[MESH] |Child[MESH] |Coronavirus Infections/*diagnosis[MESH] |Coronavirus Nucleocapsid Proteins[MESH] |False Positive Reactions[MESH] |Hong Kong[MESH] |Humans[MESH] |Immunoassay/*methods[MESH] |Molecular Diagnostic Techniques/methods[MESH] |Mucocutaneous Lymph Node Syndrome/*pathology[MESH] |Nucleocapsid Proteins/immunology[MESH] |Pandemics[MESH] |Phosphoproteins[MESH] |Pneumonia, Viral/*diagnosis[MESH] |Polymerase Chain Reaction/methods[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH] |Serologic Tests/*methods[MESH]False-positive SARS-CoV-2 serology in 3 children with Kawasaki disease(epmc).pdf DeepDyve Pubget Overpricing