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10.1021/acs.jproteome.0c00410 http://scihub22266oqcxt.onion/10.1021/acs.jproteome.0c00410 32794723!?!32794723 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32794723&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Proteome+Res 2020 ; 19 (11): 4649-4654 Nephropedia Template TP {{tp|p=32794723|t=2020. Biological Rationale for the Repurposing of BCG Vaccine against SARS-CoV-2 |pdf=|usr=}}{{32794723}} gab.com Text Biological Rationale for the Repurposing of BCG Vaccine against SARS-CoV-2 JO: J Proteome Res http://www.kidney.de/pget.php?&tw=1&pmid=32794723 #FOAvip The Bacillus Calmette-Guerin vaccine is still widely used in the developing world. The vaccination prevents infant death not only from tuberculosis but also from unrelated infectious agents, especially respiratory tract infections and neonatal sepsis. It is proposed that these off-target protective effects of the BCG vaccine are mediated by the general long-term boosting of innate immune mechanisms, also termed "trained innate immunity". Recent studies indicate that both COVID-19 incidence and total deaths are strongly associated with the presence or absence of national mandatory BCG vaccination programs and encourage the initiation of several clinical studies with the expectation that revaccination with BCG could reduce the incidence and severity of COVID-19. Here, presented results from the bioinformatics analysis of the Mycobacterium bovis (strain BCG/Pasteur 1173P2) proteome suggests four immunodominant antigens that could induce an immune response against SARS-CoV-2. Twit Text FOAVip Biological Rationale for the Repurposing of BCG Vaccine against SARS-CoV-2 ????J Proteome Res http://www.kidney.de/pget.php?&tw=1&pmid=32794723 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32794723 #FOAvip English Wikipedia <ref>{{Cite pmid|32794723}}</ref> Biological Rationale for the Repurposing of BCG Vaccine against SARS-CoV-2 #MMPMID32794723 Glisic S; Perovic VR; Sencanski M; Paessler S; Veljkovic V J Proteome Res 2020[Nov]; 19 (11): 4649-4654 PMID32794723show ga The Bacillus Calmette-Guerin vaccine is still widely used in the developing world. The vaccination prevents infant death not only from tuberculosis but also from unrelated infectious agents, especially respiratory tract infections and neonatal sepsis. It is proposed that these off-target protective effects of the BCG vaccine are mediated by the general long-term boosting of innate immune mechanisms, also termed "trained innate immunity". Recent studies indicate that both COVID-19 incidence and total deaths are strongly associated with the presence or absence of national mandatory BCG vaccination programs and encourage the initiation of several clinical studies with the expectation that revaccination with BCG could reduce the incidence and severity of COVID-19. Here, presented results from the bioinformatics analysis of the Mycobacterium bovis (strain BCG/Pasteur 1173P2) proteome suggests four immunodominant antigens that could induce an immune response against SARS-CoV-2. |*BCG Vaccine/chemistry/immunology[MESH] |*Bacterial Proteins/chemistry/immunology[MESH] |*Betacoronavirus/chemistry/immunology[MESH] |*Coronavirus Infections/immunology/prevention & control[MESH] |*Drug Repositioning[MESH] |*Pandemics/prevention & control[MESH] |*Pneumonia, Viral/immunology/prevention & control[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Humans[MESH] |Mycobacterium bovis/chemistry/immunology[MESH] |Proteome/chemistry/immunology[MESH] |SARS-CoV-2[MESH]Biological Rationale for the Repurposing of BCG Vaccine against SARS-C(epmc).pdf DeepDyve Pubget Overpricing