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10.1038/s41379-020-00649-x http://scihub22266oqcxt.onion/10.1038/s41379-020-00649-x 32792598!7424245!32792598     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mod+Pathol 2020 ; 33 (11): 2147-2155 Nephropedia Template TP {{tp|p=32792598|t=2020. Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data |pdf=|usr=}}{{32792598}} gab.com Text Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data JO: Mod Pathol http://www.kidney.de/pget.php?&tw=1&pmid=32792598 #FOAvip The novel coronavirus SARS-CoV-2 (coronavirus disease 19, or COVID-19) primarily causes pulmonary injury, but has been implicated to cause hepatic injury, both by serum markers and histologic evaluation. The histologic pattern of injury has not been completely described. Studies quantifying viral load in the liver are lacking. Here we report the clinical and histologic findings related to the liver in 40 patients who died of complications of COVID-19. A subset of liver tissue blocks were subjected to polymerase chain reaction (PCR) for viral ribonucleic acid (RNA). Peak levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were elevated; median ALT peak 68 U/l (normal up to 46 U/l) and median AST peak 102 U/l (normal up to 37 U/l). Macrovesicular steatosis was the most common finding, involving 30 patients (75%). Mild lobular necroinflammation and portal inflammation were present in 20 cases each (50%). Vascular pathology, including sinusoidal microthrombi, was infrequent, seen in six cases (15%). PCR of liver tissue was positive in 11 of 20 patients tested (55%). In conclusion, we found patients dying of COVID-19 had biochemical evidence of hepatitis (of variable severity) and demonstrated histologic findings of macrovesicular steatosis and mild acute hepatitis (lobular necroinflammation) and mild portal inflammation. We also identified viral RNA in a sizeable subset of liver tissue samples. Twit Text FOAVip Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data ????Mod Pathol http://www.kidney.de/pget.php?&tw=1&pmid=32792598 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32792598 #FOAvip English Wikipedia <ref>{{Cite pmid|32792598}}</ref> Hepatic pathology in patients dying of COVID-19: a series of 40 cases including clinical, histologic, and virologic data #MMPMID32792598 Lagana SM; Kudose S; Iuga AC; Lee MJ; Fazlollahi L; Remotti HE; Del Portillo A; De Michele S; de Gonzalez AK; Saqi A; Khairallah P; Chong AM; Park H; Uhlemann AC; Lefkowitch JH; Verna EC Mod Pathol 2020[Nov]; 33 (11): 2147-2155 PMID32792598show ga The novel coronavirus SARS-CoV-2 (coronavirus disease 19, or COVID-19) primarily causes pulmonary injury, but has been implicated to cause hepatic injury, both by serum markers and histologic evaluation. The histologic pattern of injury has not been completely described. Studies quantifying viral load in the liver are lacking. Here we report the clinical and histologic findings related to the liver in 40 patients who died of complications of COVID-19. A subset of liver tissue blocks were subjected to polymerase chain reaction (PCR) for viral ribonucleic acid (RNA). Peak levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were elevated; median ALT peak 68 U/l (normal up to 46 U/l) and median AST peak 102 U/l (normal up to 37 U/l). Macrovesicular steatosis was the most common finding, involving 30 patients (75%). Mild lobular necroinflammation and portal inflammation were present in 20 cases each (50%). Vascular pathology, including sinusoidal microthrombi, was infrequent, seen in six cases (15%). PCR of liver tissue was positive in 11 of 20 patients tested (55%). In conclusion, we found patients dying of COVID-19 had biochemical evidence of hepatitis (of variable severity) and demonstrated histologic findings of macrovesicular steatosis and mild acute hepatitis (lobular necroinflammation) and mild portal inflammation. We also identified viral RNA in a sizeable subset of liver tissue samples. |Aged[MESH] |Aged, 80 and over[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications[MESH] |Female[MESH] |Humans[MESH] |Liver Diseases/*pathology/*virology[MESH] |Male[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications[MESH]Hepatic pathology in patients dying of COVID-19: a series of 40 cases (epmc).pdf DeepDyve Pubget Overpricing