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10.1016/j.prrv.2020.07.003

http://scihub22266oqcxt.onion/10.1016/j.prrv.2020.07.003
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32792288!7387280!32792288
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suck abstract from ncbi


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pmid32792288      Paediatr+Respir+Rev 2020 ; 35 (ä): 81-87
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  • Hyperinflammation and the utility of immunomodulatory medications in children with COVID-19 #MMPMID32792288
  • Tanner T; Wahezi DM
  • Paediatr Respir Rev 2020[Sep]; 35 (ä): 81-87 PMID32792288show ga
  • The rapid spread of SARS-CoV-2 infection globally coupled with the relatively high case-fatality rate has led to immediate need for therapeutic intervention to prevent and treat COVID-19 disease. There is accumulating evidence that morbidity and mortality in COVID-19 may be exacerbated by a dysregulated host immune response resulting in significant hyperinflammation and cytokine release. The aim of this review is to describe the basis for the immune dysregulation caused by SARS-CoV-2 infection and to examine current investigations into immunomodulatory therapies aimed at targeting the excessive host immune response.
  • |Adrenal Cortex Hormones/therapeutic use[MESH]
  • |Antibodies, Monoclonal, Humanized/therapeutic use[MESH]
  • |Antigen-Antibody Complex/immunology[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |Child[MESH]
  • |Coronavirus Infections/drug therapy/*immunology/physiopathology/therapy[MESH]
  • |Cytokine Release Syndrome/*immunology/physiopathology/therapy[MESH]
  • |Humans[MESH]
  • |Immunization, Passive/methods[MESH]
  • |Immunoglobulins, Intravenous/therapeutic use[MESH]
  • |Immunologic Factors/*therapeutic use[MESH]
  • |Inflammation/immunology/physiopathology/therapy[MESH]
  • |Interleukin 1 Receptor Antagonist Protein/therapeutic use[MESH]
  • |Janus Kinase Inhibitors/therapeutic use[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*immunology/physiopathology/therapy[MESH]
  • |Receptors, Interleukin-6/antagonists & inhibitors[MESH]
  • |SARS-CoV-2[MESH]


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