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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Paediatr+Respir+Rev 2020 ; 35 (ä): 81-87 Nephropedia Template TP
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Hyperinflammation and the utility of immunomodulatory medications in children with COVID-19 #MMPMID32792288
Tanner T; Wahezi DM
Paediatr Respir Rev 2020[Sep]; 35 (ä): 81-87 PMID32792288show ga
The rapid spread of SARS-CoV-2 infection globally coupled with the relatively high case-fatality rate has led to immediate need for therapeutic intervention to prevent and treat COVID-19 disease. There is accumulating evidence that morbidity and mortality in COVID-19 may be exacerbated by a dysregulated host immune response resulting in significant hyperinflammation and cytokine release. The aim of this review is to describe the basis for the immune dysregulation caused by SARS-CoV-2 infection and to examine current investigations into immunomodulatory therapies aimed at targeting the excessive host immune response.