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10.1016/j.bios.2020.112494

http://scihub22266oqcxt.onion/10.1016/j.bios.2020.112494
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32791468!7403137!32791468
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suck abstract from ncbi


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pmid32791468      Biosens+Bioelectron 2020 ; 167 (ä): 112494
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  • G-quadruplex based biosensor: A potential tool for SARS-CoV-2 detection #MMPMID32791468
  • Xi H; Juhas M; Zhang Y
  • Biosens Bioelectron 2020[Nov]; 167 (ä): 112494 PMID32791468show ga
  • G-quadruplex is a non-canonical nucleic acid structure formed by the folding of guanine rich DNA or RNA. The conformation and function of G-quadruplex are determined by a number of factors, including the number and polarity of nucleotide strands, the type of cations and the binding targets. Recent studies led to the discovery of additional advantageous attributes of G-quadruplex with the potential to be used in novel biosensors, such as improved ligand binding and unique folding properties. G-quadruplex based biosensor can detect various substances, such as metal ions, organic macromolecules, proteins and nucleic acids with improved affinity and specificity compared to standard biosensors. The recently developed G-quadruplex based biosensors include electrochemical and optical biosensors. A novel G-quadruplex based biosensors also show better performance and broader applications in the detection of a wide spectrum of pathogens, including SARS-CoV-2, the causative agent of COVID-19 disease. This review highlights the latest developments in the field of G-quadruplex based biosensors, with particular focus on the G-quadruplex sequences and recent applications and the potential of G-quadruplex based biosensors in SARS-CoV-2 detection.
  • |*Betacoronavirus/genetics/isolation & purification[MESH]
  • |*G-Quadruplexes[MESH]
  • |Biosensing Techniques/*methods/trends[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |Clinical Laboratory Techniques/*methods/trends[MESH]
  • |Colorimetry[MESH]
  • |Coronavirus Infections/*diagnosis/*virology[MESH]
  • |Electrochemical Techniques[MESH]
  • |Fluorescent Dyes[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*diagnosis/*virology[MESH]


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