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10.1016/j.meegid.2020.104497

http://scihub22266oqcxt.onion/10.1016/j.meegid.2020.104497
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32791240!7417262!32791240
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suck abstract from ncbi


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pmid32791240      Infect+Genet+Evol 2020 ; 85 (ä): 104497
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  • Repurposing of SARS-CoV nucleocapsid protein specific nuclease resistant RNA aptamer for therapeutics against SARS-CoV-2 #MMPMID32791240
  • Parashar NC; Poddar J; Chakrabarti S; Parashar G
  • Infect Genet Evol 2020[Nov]; 85 (ä): 104497 PMID32791240show ga
  • COVID-19 pandemic is rapidly advancing among human population. Development of new interventions including therapeutics and vaccines against SARS-CoV-2 will require time and validation before it could be made available for public use. Keeping in view of the emergent and evolving situation the motive is to repurpose and test the immediate efficacy of available drugs and therapeutics against COVID-19. Through this article we propose and discuss the possibility of repurposing the available nuclease resistant RNA aptamer against the nucleocapsid protein of SARS-CoV as a potential therapeutic agent for COVID-19.
  • |Amino Acid Sequence[MESH]
  • |Antiviral Agents/chemistry/*pharmacology/therapeutic use[MESH]
  • |Aptamers, Nucleotide/chemistry/*pharmacology/therapeutic use[MESH]
  • |Coronavirus Nucleocapsid Proteins/antagonists & inhibitors/chemistry[MESH]
  • |Drug Repositioning[MESH]
  • |Humans[MESH]
  • |Models, Molecular[MESH]
  • |Molecular Conformation[MESH]
  • |SARS-CoV-2/drug effects/*metabolism[MESH]
  • |Spike Glycoprotein, Coronavirus/antagonists & inhibitors/chemistry[MESH]


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