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10.1016/j.cca.2020.08.008 http://scihub22266oqcxt.onion/10.1016/j.cca.2020.08.008 32791137!7416133!32791137     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32791137&cmd=llinks): Failed to open stream: HTTP request failed! 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ACE deletion allele is associated with susceptibility to SARS-CoV-2 infection and mortality rate: An epidemiological study in the Asian population |pdf=|usr=}}{{32791137}} gab.com Text ACE deletion allele is associated with susceptibility to SARS-CoV-2 infection and mortality rate: An epidemiological study in the Asian population JO: Clin Chim Acta http://www.kidney.de/pget.php?&tw=1&pmid=32791137 #FOAvip BACKGROUND: Severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) is believed to have emerged from Wuhan, China, and spreads over 215 countries worldwide. The spike protein of SARS-CoV-2 binds to angiotensin-converting enzyme-2 (ACE-2) receptors and enter the host cells. Several reports have been highlighted the importance of ACE-2 on the pathogenesis of COVID-19. In the present study, we hypothesize that a functional insertion/deletion polymorphism in the ACE gene could be associated with SARS-CoV-2 infection and mortality. MATERIALS AND METHODS: PubMed and Google scholar search engines were used to obtained data on the prevalence of ACE I/D polymorphism in different countries of the Asia continent. Data on COVID-19 infection rate (per million), mortality/million, and percentage of recovery were acquired form worldometer website. The Spearman rank correlation test performed to investigate the correlation of allele 'D' with SARS-CoV-2 infection, mortality rate, and recovery percentage. RESULTS: Epidemiological investigation revealed a significant positive correlation of D allele of ACE polymorphism with SARS-CoV-2 infection (r = 0.502, p = 0.008, n = 26) and mortality rate (r = 0.620, p = 0.002, n = 22) in Asian population. However, no significant role of ACE I/D polymorphism was observed with recovery rate of patients from SARS-CoV-2 infection (r = -0.208, p = 0.352, n = 22). CONCLUSIONS: Allele D of ACE insertion/deletion polymorphism is associated with the rate of infection and mortality in the Asian population. Twit Text FOAVip ACE deletion allele is associated with susceptibility to SARS-CoV-2 infection and mortality rate: An epidemiological study in the Asian population ????Clin Chim Acta http://www.kidney.de/pget.php?&tw=1&pmid=32791137 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32791137 #FOAvip English Wikipedia <ref>{{Cite pmid|32791137}}</ref> ACE deletion allele is associated with susceptibility to SARS-CoV-2 infection and mortality rate: An epidemiological study in the Asian population #MMPMID32791137 Pati A; Mahto H; Padhi S; Panda AK Clin Chim Acta 2020[Nov]; 510 (ä): 455-458 PMID32791137show ga BACKGROUND: Severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) is believed to have emerged from Wuhan, China, and spreads over 215 countries worldwide. The spike protein of SARS-CoV-2 binds to angiotensin-converting enzyme-2 (ACE-2) receptors and enter the host cells. Several reports have been highlighted the importance of ACE-2 on the pathogenesis of COVID-19. In the present study, we hypothesize that a functional insertion/deletion polymorphism in the ACE gene could be associated with SARS-CoV-2 infection and mortality. MATERIALS AND METHODS: PubMed and Google scholar search engines were used to obtained data on the prevalence of ACE I/D polymorphism in different countries of the Asia continent. Data on COVID-19 infection rate (per million), mortality/million, and percentage of recovery were acquired form worldometer website. The Spearman rank correlation test performed to investigate the correlation of allele 'D' with SARS-CoV-2 infection, mortality rate, and recovery percentage. RESULTS: Epidemiological investigation revealed a significant positive correlation of D allele of ACE polymorphism with SARS-CoV-2 infection (r = 0.502, p = 0.008, n = 26) and mortality rate (r = 0.620, p = 0.002, n = 22) in Asian population. However, no significant role of ACE I/D polymorphism was observed with recovery rate of patients from SARS-CoV-2 infection (r = -0.208, p = 0.352, n = 22). CONCLUSIONS: Allele D of ACE insertion/deletion polymorphism is associated with the rate of infection and mortality in the Asian population. |*Alleles[MESH] |*Sequence Deletion[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Asian People/*genetics[MESH] |COVID-19[MESH] |Coronavirus Infections/enzymology/*epidemiology/*genetics[MESH] |Genetic Predisposition to Disease/*genetics[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*genetics[MESH] |Pneumonia, Viral/enzymology/*epidemiology/*genetics[MESH]ACE deletion allele is associated with susceptibility to SARS-CoV-2 in(epmc).pdf DeepDyve Pubget Overpricing