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10.1021/acs.jpclett.0c01431 http://scihub22266oqcxt.onion/10.1021/acs.jpclett.0c01431 32787330!ä!32787330 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Phys+Chem+Lett 2020 ; 11 (17): 7021-7027 Nephropedia Template TP {{tp|p=32787330|t=2020. Dynamic Asymmetry Exposes 2019-nCoV Prefusion Spike |pdf=|usr=}}{{32787330}} gab.com Text Dynamic Asymmetry Exposes 2019-nCoV Prefusion Spike JO: J Phys Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=32787330 #FOAvip The novel coronavirus (2019-nCoV) spike protein is a smart molecular machine that instigates the entry of coronavirus to the host cell causing the COVID-19 pandemic. In this study, a symmetry-information-loaded structure-based Hamiltonian is developed using recent Cryo-EM structural data to explore the complete conformational energy landscape of the full-length prefusion spike protein. The study finds the 2019-nCoV prefusion spike to adopt a unique strategy by undertaking a dynamic conformational asymmetry that results in two prevalent asymmetric structures of spike where one or two spike heads rotate up to provide better exposure to the host-cell receptor. A few unique interchain interactions are identified at the interface of closely associated N-terminal domain (NTD) and receptor binding domain (RBD) playing a crucial role in the thermodynamic stabilization of the up conformation of the RBD in the case of the 2019-nCoV spike. The interaction-level information decoded in this study may provide deep insight into developing effective therapeutic targets. Twit Text FOAVip Dynamic Asymmetry Exposes 2019-nCoV Prefusion Spike ????J Phys Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=32787330 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32787330 #FOAvip English Wikipedia <ref>{{Cite pmid|32787330}}</ref> Dynamic Asymmetry Exposes 2019-nCoV Prefusion Spike #MMPMID32787330 Roy S; Jaiswar A; Sarkar R J Phys Chem Lett 2020[Sep]; 11 (17): 7021-7027 PMID32787330show ga The novel coronavirus (2019-nCoV) spike protein is a smart molecular machine that instigates the entry of coronavirus to the host cell causing the COVID-19 pandemic. In this study, a symmetry-information-loaded structure-based Hamiltonian is developed using recent Cryo-EM structural data to explore the complete conformational energy landscape of the full-length prefusion spike protein. The study finds the 2019-nCoV prefusion spike to adopt a unique strategy by undertaking a dynamic conformational asymmetry that results in two prevalent asymmetric structures of spike where one or two spike heads rotate up to provide better exposure to the host-cell receptor. A few unique interchain interactions are identified at the interface of closely associated N-terminal domain (NTD) and receptor binding domain (RBD) playing a crucial role in the thermodynamic stabilization of the up conformation of the RBD in the case of the 2019-nCoV spike. The interaction-level information decoded in this study may provide deep insight into developing effective therapeutic targets. |Models, Molecular[MESH] |Protein Domains[MESH] |Spike Glycoprotein, Coronavirus/*chemistry/*metabolism[MESH]Dynamic Asymmetry Exposes 2019-nCoV Prefusion Spike (epmc).pdf DeepDyve Pubget Overpricing