Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1021/acs.biochem.0c00591 http://scihub22266oqcxt.onion/10.1021/acs.biochem.0c00591 32786401!7418565!32786401     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochemistry 2020 ; 59 (33): 3038-3043 Nephropedia Template TP {{tp|p=32786401|t=2020. A Chemoenzymatic Synthesis of the (R(P))-Isomer of the Antiviral Prodrug Remdesivir |pdf=|usr=}}{{32786401}} gab.com Text A Chemoenzymatic Synthesis of the (R(P))-Isomer of the Antiviral Prodrug Remdesivir JO: Biochemistry http://www.kidney.de/pget.php?&tw=1&pmid=32786401 #FOAvip The COVID-19 pandemic threatens to overwhelm healthcare systems around the world. The only current FDA-approved treatment, which directly targets the virus, is the ProTide prodrug remdesivir. In its activated form, remdesivir prevents viral replication by inhibiting the essential RNA-dependent RNA polymerase. Like other ProTide prodrugs, remdesivir contains a chiral phosphorus center. The initial selection of the (S(P))-diastereomer for remdesivir was reportedly due to the difficulty in producing the pure (R(P))-diastereomer of the required precursor. However, the two currently known enzymes responsible for the initial activation step of remdesivir are each stereoselective and show differential tissue distribution. Given the ability of the COVID-19 virus to infect a wide array of tissue types, inclusion of the (R(P))-diastereomer may be of clinical significance. To help overcome the challenge of obtaining the pure (R(P))-diastereomer of remdesivir, we have developed a novel chemoenzymatic strategy that utilizes a stereoselective variant of the phosphotriesterase from Pseudomonas diminuta to enable the facile isolation of the pure (R(P))-diastereomer of the chiral precursor for the chemical synthesis of the (R(P))-diastereomer of remdesivir. Twit Text FOAVip A Chemoenzymatic Synthesis of the (R(P))-Isomer of the Antiviral Prodrug Remdesivir ????Biochemistry http://www.kidney.de/pget.php?&tw=1&pmid=32786401 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32786401 #FOAvip English Wikipedia <ref>{{Cite pmid|32786401}}</ref> A Chemoenzymatic Synthesis of the (R(P))-Isomer of the Antiviral Prodrug Remdesivir #MMPMID32786401 Bigley AN; Narindoshvili T; Raushel FM Biochemistry 2020[Aug]; 59 (33): 3038-3043 PMID32786401show ga The COVID-19 pandemic threatens to overwhelm healthcare systems around the world. The only current FDA-approved treatment, which directly targets the virus, is the ProTide prodrug remdesivir. In its activated form, remdesivir prevents viral replication by inhibiting the essential RNA-dependent RNA polymerase. Like other ProTide prodrugs, remdesivir contains a chiral phosphorus center. The initial selection of the (S(P))-diastereomer for remdesivir was reportedly due to the difficulty in producing the pure (R(P))-diastereomer of the required precursor. However, the two currently known enzymes responsible for the initial activation step of remdesivir are each stereoselective and show differential tissue distribution. Given the ability of the COVID-19 virus to infect a wide array of tissue types, inclusion of the (R(P))-diastereomer may be of clinical significance. To help overcome the challenge of obtaining the pure (R(P))-diastereomer of remdesivir, we have developed a novel chemoenzymatic strategy that utilizes a stereoselective variant of the phosphotriesterase from Pseudomonas diminuta to enable the facile isolation of the pure (R(P))-diastereomer of the chiral precursor for the chemical synthesis of the (R(P))-diastereomer of remdesivir. |Adenosine Monophosphate/*analogs & derivatives/chemical synthesis[MESH] |Alanine/*analogs & derivatives/chemical synthesis[MESH] |Antiviral Agents/*chemical synthesis[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Caulobacteraceae/enzymology[MESH] |Coronavirus Infections[MESH] |Humans[MESH] |Molecular Structure[MESH] |Pandemics[MESH] |Phosphoric Triester Hydrolases/chemistry[MESH] |Pneumonia, Viral[MESH] |RNA-Dependent RNA Polymerase/antagonists & inhibitors[MESH] |SARS-CoV-2[MESH]A Chemoenzymatic Synthesis of the (R(P))-Isomer of the Antiviral Prodr(epmc).pdf DeepDyve Pubget Overpricing