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10.1083/jcb.202006159 http://scihub22266oqcxt.onion/10.1083/jcb.202006159 32785687!7659715!32785687     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Biol 2020 ; 219 (10): ä Nephropedia Template TP {{tp|p=32785687|t=2020. Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality |pdf=|usr=}}{{32785687}} gab.com Text Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=32785687 #FOAvip With the rapid global spread of SARS-CoV-2, we have become acutely aware of the inadequacies of our ability to respond to viral epidemics. Although disrupting the viral life cycle is critical for limiting viral spread and disease, it has proven challenging to develop targeted and selective therapeutics. Synthetic lethality offers a promising but largely unexploited strategy against infectious viral disease; as viruses infect cells, they abnormally alter the cell state, unwittingly exposing new vulnerabilities in the infected cell. Therefore, we propose that effective therapies can be developed to selectively target the virally reconfigured host cell networks that accompany altered cellular states to cripple the host cell that has been converted into a virus factory, thus disrupting the viral life cycle. Twit Text FOAVip Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=32785687 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32785687 #FOAvip English Wikipedia <ref>{{Cite pmid|32785687}}</ref> Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality #MMPMID32785687 Mast FD; Navare AT; van der Sloot AM; Coulombe-Huntington J; Rout MP; Baliga NS; Kaushansky A; Chait BT; Aderem A; Rice CM; Sali A; Tyers M; Aitchison JD J Cell Biol 2020[Oct]; 219 (10): ä PMID32785687show ga With the rapid global spread of SARS-CoV-2, we have become acutely aware of the inadequacies of our ability to respond to viral epidemics. Although disrupting the viral life cycle is critical for limiting viral spread and disease, it has proven challenging to develop targeted and selective therapeutics. Synthetic lethality offers a promising but largely unexploited strategy against infectious viral disease; as viruses infect cells, they abnormally alter the cell state, unwittingly exposing new vulnerabilities in the infected cell. Therefore, we propose that effective therapies can be developed to selectively target the virally reconfigured host cell networks that accompany altered cellular states to cripple the host cell that has been converted into a virus factory, thus disrupting the viral life cycle. |Antiviral Agents/*pharmacology[MESH] |Drug Discovery[MESH] |Host Microbial Interactions/*drug effects[MESH] |Humans[MESH] |Immunologic Factors/pharmacology[MESH] |Metabolic Networks and Pathways/drug effects[MESH] |Protein Interaction Maps[MESH] |Proteolysis[MESH] |RNA Viruses/drug effects/physiology[MESH] |Virus Diseases/*drug therapy/genetics[MESH]Crippling life support for SARS-CoV-2 and other viruses through synthe(epmc).pdf DeepDyve Pubget Overpricing