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10.3390/nu12082391

http://scihub22266oqcxt.onion/10.3390/nu12082391
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32785021!7468764!32785021
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suck abstract from ncbi


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pmid32785021      Nutrients 2020 ; 12 (8): ä
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  • A Five-Ingredient Nutritional Supplement and Home-Based Resistance Exercise Improve Lean Mass and Strength in Free-Living Elderly #MMPMID32785021
  • Nilsson MI; Mikhail A; Lan L; Di Carlo A; Hamilton B; Barnard K; Hettinga BP; Hatcher E; Tarnopolsky MG; Nederveen JP; Bujak AL; May L; Tarnopolsky MA
  • Nutrients 2020[Aug]; 12 (8): ä PMID32785021show ga
  • Old age is associated with lower physical activity levels, suboptimal protein intake, and desensitization to anabolic stimuli, predisposing for age-related muscle loss (sarcopenia). Although resistance exercise (RE) and protein supplementation partially protect against sarcopenia under controlled conditions, the efficacy of home-based, unsupervised RE (HBRE) and multi-ingredient supplementation (MIS) is largely unknown. In this randomized, placebo-controlled and double-blind trial, we examined the effects of HBRE/MIS on muscle mass, strength, and function in free-living, older men. Thirty-two sedentary men underwent twelve weeks of home-based resistance band training (3 d/week), in combination with daily intake of a novel five-nutrient supplement ('Muscle5'; M5, n = 16, 77.4 +/- 2.8 y) containing whey, micellar casein, creatine, vitamin D, and omega-3 fatty acids, or an isocaloric/isonitrogenous placebo (PLA; n = 16, 74.4 +/- 1.3 y), containing collagen and sunflower oil. Appendicular and total lean mass (ASM; +3%, TLM; +2%), lean mass to fat ratios (ASM/% body fat; +6%, TLM/% body fat; +5%), maximal strength (grip; +8%, leg press; +17%), and function (5-Times Sit-to-Stand time; -9%) were significantly improved in the M5 group following HBRE/MIS therapy (pre vs. post tests; p < 0.05). Fast-twitch muscle fiber cross-sectional areas of the quadriceps muscle were also significantly increased in the M5 group post intervention (Type IIa; +30.9%, Type IIx, +28.5%, p < 0.05). Sub-group analysis indicated even greater gains in total lean mass in sarcopenic individuals following HBRE/MIS therapy (TLM; +1.65 kg/+3.4%, p < 0.05). We conclude that the Muscle5 supplement is a safe, well-tolerated, and effective complement to low-intensity, home-based resistance exercise and improves lean mass, strength, and overall muscle quality in old age.
  • |*Body Composition[MESH]
  • |*Dietary Supplements[MESH]
  • |*Muscle Strength[MESH]
  • |*Resistance Training[MESH]
  • |Aged[MESH]
  • |Anabolic Agents/therapeutic use[MESH]
  • |Body Fluid Compartments[MESH]
  • |Caseins/therapeutic use[MESH]
  • |Combined Modality Therapy[MESH]
  • |Creatine/therapeutic use[MESH]
  • |Double-Blind Method[MESH]
  • |Exercise[MESH]
  • |Fatty Acids, Omega-3/therapeutic use[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Muscle Fibers, Fast-Twitch[MESH]
  • |Muscle Proteins[MESH]
  • |Muscle, Skeletal/drug effects/metabolism/*physiology[MESH]
  • |Quadriceps Muscle[MESH]
  • |Sarcopenia/physiopathology/*therapy[MESH]
  • |Self Care[MESH]
  • |Vitamin D/therapeutic use[MESH]
  • |Vitamins[MESH]


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