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10.3390/ijms21165707 http://scihub22266oqcxt.onion/10.3390/ijms21165707 32784899!7460888!32784899     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32784899&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Int+J+Mol+Sci 2020 ; 21 (16): ? Nephropedia Template TP {{tp|p=32784899|t=2020. SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells |pdf=|usr=}}{{32784899}} gab.com Text SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32784899 #FOAvip The pandemic evolution of SARS-CoV-2 infection is forcing the scientific community to unprecedented efforts to explore all possible approaches against COVID-19. In this context, targeting virus entry is a promising antiviral strategy for controlling viral infections. The main strategies pursued to inhibit the viral entry are considering both the virus and the host factors involved in the process. Primarily, direct-acting antivirals rely on inhibition of the interaction between ACE2 and the receptor binding domain (RBD) of the Spike (S) protein or targeting the more conserved heptad repeats (HRs), involved in the membrane fusion process. The inhibition of host TMPRSS2 and cathepsins B/L may represent a complementary strategy to be investigated. In this review, we discuss the development entry inhibitors targeting the S protein, as well as the most promising host targeting strategies involving TMPRSS2 and CatB/L, which have been exploited so far against CoVs and other related viruses. Twit Text FOAVip SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=32784899 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32784899 #FOAvip English Wikipedia <ref>{{Cite pmid|32784899}}</ref> SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Virus or Host Cells #MMPMID32784899 Cannalire R; Stefanelli I; Cerchia C; Beccari AR; Pelliccia S; Summa V Int J Mol Sci 2020[Aug]; 21 (16): ? PMID32784899show ga The pandemic evolution of SARS-CoV-2 infection is forcing the scientific community to unprecedented efforts to explore all possible approaches against COVID-19. In this context, targeting virus entry is a promising antiviral strategy for controlling viral infections. The main strategies pursued to inhibit the viral entry are considering both the virus and the host factors involved in the process. Primarily, direct-acting antivirals rely on inhibition of the interaction between ACE2 and the receptor binding domain (RBD) of the Spike (S) protein or targeting the more conserved heptad repeats (HRs), involved in the membrane fusion process. The inhibition of host TMPRSS2 and cathepsins B/L may represent a complementary strategy to be investigated. In this review, we discuss the development entry inhibitors targeting the S protein, as well as the most promising host targeting strategies involving TMPRSS2 and CatB/L, which have been exploited so far against CoVs and other related viruses. |Angiotensin-Converting Enzyme Inhibitors/*pharmacology[MESH] |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Betacoronavirus/*drug effects/metabolism/physiology[MESH] |Humans[MESH] |SARS-CoV-2[MESH] |Serine Proteinase Inhibitors/*pharmacology[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH]SARS-CoV-2 Entry Inhibitors: Small Molecules and Peptides Targeting Vi(epmc).pdf DeepDyve Pubget Overpricing