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10.1136/jitc-2020-001089

http://scihub22266oqcxt.onion/10.1136/jitc-2020-001089
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32784217!7418768!32784217
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suck abstract from ncbi


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pmid32784217      J+Immunother+Cancer 2020 ; 8 (2): ä
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  • Outcomes and biomarker analyses among patients with COVID-19 treated with interleukin 6 (IL-6) receptor antagonist sarilumab at a single institution in Italy #MMPMID32784217
  • Montesarchio V; Parrela R; Iommelli C; Bianco A; Manzillo E; Fraganza F; Palumbo C; Rea G; Murino P; De Rosa R; Atripaldi L; D'Abbraccio M; Curvietto M; Mallardo D; Celentano E; Grimaldi AM; Palla M; Trojaniello C; Vitale MG; Million-Weaver SL; Ascierto PA
  • J Immunother Cancer 2020[Aug]; 8 (2): ä PMID32784217show ga
  • BACKGROUND: The inflammatory pathology observed in severe COVID-19 disease caused by the 2019 novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by elevated serum levels of C reactive protein (CRP) and cytokines, including interferon gamma, interleukin 8 (IL-8), and interleukin 6 (IL-6). Initial reports from the outbreak in Italy, China and the USA have provided anecdotal evidence of improved outcomes with the administration of anti-IL-6 agents, and large-scale trials evaluating these therapies are ongoing. STUDY DESCRIPTION: In this retrospective case series, clinical outcomes and correlates of response to treatment with the IL-6 receptor antagonist sarilumab are described for 15 patients with COVID-19 from a single institution in Southern Italy. Among 10 patients whose symptoms improved after sarilumab treatment, rapid decreases in CRP levels corresponded with clinical improvement. Lower levels of IL-6 at baseline as well as lower neutrophil to lymphocyte ratio as compared with patients whose COVID-19 did not improve with treatment were associated with sarilumab-responsive disease. CONCLUSIONS: This observation may reflect a possible clinical benefit regarding early intervention with IL-6-modulatory therapies for COVID-19 and that CRP could be a potential biomarker of response to treatment.
  • |Aged[MESH]
  • |Antibodies, Monoclonal, Humanized/*therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |Biomarkers, Pharmacological/*blood[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/complications/diagnostic imaging/*drug therapy[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interleukin-6/*blood[MESH]
  • |Italy[MESH]
  • |Lymphocyte Count[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Neutrophils[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/diagnostic imaging/*drug therapy[MESH]
  • |Receptors, Interleukin-6/antagonists & inhibitors[MESH]
  • |Retrospective Studies[MESH]


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