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10.1016/j.coviro.2020.07.003

http://scihub22266oqcxt.onion/10.1016/j.coviro.2020.07.003
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32784125!7415341!32784125
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suck abstract from ncbi


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pmid32784125      Curr+Opin+Virol 2020 ; 44 (ä): 97-111
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  • Natural killer cell responses to emerging viruses of zoonotic origin #MMPMID32784125
  • Diaz-Salazar C; Sun JC
  • Curr Opin Virol 2020[Oct]; 44 (ä): 97-111 PMID32784125show ga
  • Emerging viral diseases pose a major threat to public health worldwide. Nearly all emerging viruses, including Ebola, Dengue, Nipah, West Nile, Zika, and coronaviruses (including SARS-Cov2, the causative agent of the current COVID-19 pandemic), have zoonotic origins, indicating that animal-to-human transmission constitutes a primary mode of acquisition of novel infectious diseases. Why these viruses can cause profound pathologies in humans, while natural reservoir hosts often show little evidence of disease is not completely understood. Differences in the host immune response, especially within the innate compartment, have been suggested to be involved in this divergence. Natural killer (NK) cells are innate lymphocytes that play a critical role in the early antiviral response, secreting effector cytokines and clearing infected cells. In this review, we will discuss the mechanisms through which NK cells interact with viruses, their contribution towards maintaining equilibrium between the virus and its natural host, and their role in disease progression in humans and other non-natural hosts.
  • |Animals[MESH]
  • |COVID-19/immunology/transmission[MESH]
  • |Chiroptera/virology[MESH]
  • |Communicable Diseases, Emerging/*immunology/*transmission[MESH]
  • |Haplorhini/virology[MESH]
  • |Humans[MESH]
  • |Killer Cells, Natural/*immunology[MESH]
  • |Rodentia/virology[MESH]
  • |SARS-CoV-2/immunology[MESH]
  • |Severe Acute Respiratory Syndrome/immunology/transmission[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/immunology[MESH]


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