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10.1017/ice.2020.417

http://scihub22266oqcxt.onion/10.1017/ice.2020.417
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32783787!7463154!32783787
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suck abstract from ncbi


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pmid32783787      Infect+Control+Hosp+Epidemiol 2021 ; 42 (3): 253-260
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  • Inactivation of Severe Acute Respiratory Coronavirus Virus 2 (SARS-CoV-2) and Diverse RNA and DNA Viruses on Three-Dimensionally Printed Surgical Mask Materials #MMPMID32783787
  • Welch JL; Xiang J; Mackin SR; Perlman S; Thorne P; O'Shaughnessy P; Strzelecki B; Aubin P; Ortiz-Hernandez M; Stapleton JT
  • Infect Control Hosp Epidemiol 2021[Mar]; 42 (3): 253-260 PMID32783787show ga
  • BACKGROUND: Personal protective equipment (PPE) is a critical need during the coronavirus disease 2019 (COVID-19) pandemic. Alternative sources of surgical masks, including 3-dimensionally (3D) printed approaches that may be reused, are urgently needed to prevent PPE shortages. Few data exist identifying decontamination strategies to inactivate viral pathogens and retain 3D-printing material integrity. OBJECTIVE: To test viral disinfection methods on 3D-printing materials. METHODS: The viricidal activity of common disinfectants (10% bleach, quaternary ammonium sanitizer, 3% hydrogen peroxide, or 70% isopropanol and exposure to heat (50 degrees C, and 70 degrees C) were tested on four 3D-printed materials used in the healthcare setting, including a surgical mask design developed by the Veterans' Health Administration. Inactivation was assessed for several clinically relevant RNA and DNA pathogenic viruses, including severe acute respiratory coronavirus virus 2 (SARS-CoV-2) and human immunodeficiency virus 1 (HIV-1). RESULTS: SARS-CoV-2 and all viruses tested were completely inactivated by a single application of bleach, ammonium quaternary compounds, or hydrogen peroxide. Similarly, exposure to dry heat (70 degrees C) for 30 minutes completely inactivated all viruses tested. In contrast, 70% isopropanol reduced viral titers significantly less well following a single application. Inactivation did not interfere with material integrity of the 3D-printed materials. CONCLUSIONS: Several standard decontamination approaches effectively disinfected 3D-printed materials. These approaches were effective in the inactivation SARS-CoV-2, its surrogates, and other clinically relevant viral pathogens. The decontamination of 3D-printed surgical mask materials may be useful during crisis situations in which surgical mask supplies are limited.
  • |*Masks[MESH]
  • |*Virus Inactivation[MESH]
  • |2-Propanol[MESH]
  • |COVID-19/*prevention & control[MESH]
  • |DNA, Viral/drug effects[MESH]
  • |Decontamination/methods[MESH]
  • |Disinfectants/*pharmacology[MESH]
  • |Disinfection/*methods[MESH]
  • |HIV-1/drug effects[MESH]
  • |Healthy Volunteers[MESH]
  • |Hot Temperature[MESH]
  • |Humans[MESH]
  • |Hydrogen Peroxide[MESH]
  • |Personal Protective Equipment[MESH]
  • |Printing, Three-Dimensional[MESH]
  • |RNA, Viral/drug effects[MESH]
  • |SARS-CoV-2/*drug effects[MESH]


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