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Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Hum+Vaccin+Immunother 2021 ; 17 (1): 62-83 Nephropedia Template TP
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Product of natural evolution (SARS, MERS, and SARS-CoV-2); deadly diseases, from SARS to SARS-CoV-2 #MMPMID32783700
Shahrajabian MH; Sun W; Cheng Q
Hum Vaccin Immunother 2021[Jan]; 17 (1): 62-83 PMID32783700show ga
SARS-CoV-2, the virus causing COVID-19, is a single-stranded RNA virus belonging to the order Nidovirales, family Coronaviridae, and subfamily Coronavirinae. SARS-CoV-2 entry to cellsis initiated by the binding of the viral spike protein (S) to its cellular receptor. The roles of S protein in receptor binding and membrane fusion makes it a prominent target for vaccine development. SARS-CoV-2 genome sequence analysis has shown that this virus belongs to the beta-coronavirus genus, which includes Bat SARS-like coronavirus, SARS-CoV and MERS-CoV. A vaccine should induce a balanced immune response to elicit protective immunity. In this review, we compare and contrast these three important CoV diseases and how they inform on vaccine development.
|Animals[MESH]
|COVID-19/virology[MESH]
|Chiroptera/virology[MESH]
|Humans[MESH]
|Middle East Respiratory Syndrome Coronavirus/*genetics[MESH]