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10.1152/ajplung.00283.2020 http://scihub22266oqcxt.onion/10.1152/ajplung.00283.2020 32783615!7516383!32783615     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Lung+Cell+Mol+Physiol 2020 ; 319 (4): L603-L619 Nephropedia Template TP {{tp|p=32783615|t=2020. First contact: the role of respiratory cilia in host-pathogen interactions in the airways |pdf=|usr=}}{{32783615}} gab.com Text First contact: the role of respiratory cilia in host-pathogen interactions in the airways JO: Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32783615 #FOAvip Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction with secreted airway mucus to clear inhaled debris and pathogens from the conducting airways. Respiratory cilia are also one of the first contact points between host and inhaled pathogens. Impaired ciliary function is a common pathological feature in patients with chronic airway diseases, increasing susceptibility to respiratory infections. Common respiratory pathogens, including viruses, bacteria, and fungi, have been shown to target cilia and/or ciliated airway epithelial cells, resulting in a disruption of mucociliary clearance that may facilitate host infection. Despite being an integral component of airway innate immunity, the role of respiratory cilia and their clinical significance during airway infections are still poorly understood. This review examines the expression, structure, and function of respiratory cilia during pathogenic infection of the airways. This review also discusses specific known points of interaction of bacteria, fungi, and viruses with respiratory cilia function. The emerging biological functions of motile cilia relating to intracellular signaling and their potential immunoregulatory roles during infection will also be discussed. Twit Text FOAVip First contact: the role of respiratory cilia in host-pathogen interactions in the airways ????Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=32783615 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32783615 #FOAvip English Wikipedia <ref>{{Cite pmid|32783615}}</ref> First contact: the role of respiratory cilia in host-pathogen interactions in the airways #MMPMID32783615 Kuek LE; Lee RJ Am J Physiol Lung Cell Mol Physiol 2020[Oct]; 319 (4): L603-L619 PMID32783615show ga Respiratory cilia are the driving force of the mucociliary escalator, working in conjunction with secreted airway mucus to clear inhaled debris and pathogens from the conducting airways. Respiratory cilia are also one of the first contact points between host and inhaled pathogens. Impaired ciliary function is a common pathological feature in patients with chronic airway diseases, increasing susceptibility to respiratory infections. Common respiratory pathogens, including viruses, bacteria, and fungi, have been shown to target cilia and/or ciliated airway epithelial cells, resulting in a disruption of mucociliary clearance that may facilitate host infection. Despite being an integral component of airway innate immunity, the role of respiratory cilia and their clinical significance during airway infections are still poorly understood. This review examines the expression, structure, and function of respiratory cilia during pathogenic infection of the airways. This review also discusses specific known points of interaction of bacteria, fungi, and viruses with respiratory cilia function. The emerging biological functions of motile cilia relating to intracellular signaling and their potential immunoregulatory roles during infection will also be discussed. |Bacteria/*immunology[MESH] |Cilia/*metabolism[MESH] |Epithelial Cells/metabolism[MESH] |Fungi/*immunology[MESH] |Host-Pathogen Interactions/immunology[MESH] |Humans[MESH] |Immunity, Innate/immunology[MESH] |Mucociliary Clearance/*physiology[MESH] |Mucus/metabolism[MESH] |Respiratory System/immunology[MESH]First contact: the role of respiratory cilia in host-pathogen interact(epmc).pdf DeepDyve Pubget Overpricing