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10.1152/physiol.00019.2020

http://scihub22266oqcxt.onion/10.1152/physiol.00019.2020
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32783610!7426542!32783610
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suck abstract from ncbi


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pmid32783610      Physiology+(Bethesda) 2020 ; 35 (5): 288-301
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  • Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression #MMPMID32783610
  • Bohn MK; Hall A; Sepiashvili L; Jung B; Steele S; Adeli K
  • Physiology (Bethesda) 2020[Sep]; 35 (5): 288-301 PMID32783610show ga
  • The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. This review highlights key mechanisms that have been proposed to contribute to COVID-19 progression from viral entry to multisystem organ failure, as well as the central role of the immune response in successful viral clearance or progression to death.
  • |Betacoronavirus/*pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*physiopathology/*virology[MESH]
  • |Cytokines/metabolism[MESH]
  • |Disease Progression[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*physiopathology/*virology[MESH]


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