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10.1038/s41577-020-00410-0 http://scihub22266oqcxt.onion/10.1038/s41577-020-00410-0 32782358!7418887!32782358     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Immunol 2020 ; 20 (10): 633-643 Nephropedia Template TP {{tp|p=32782358|t=2020. The role of IgG Fc receptors in antibody-dependent enhancement |pdf=|usr=}}{{32782358}} gab.com Text The role of IgG Fc receptors in antibody-dependent enhancement JO: Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32782358 #FOAvip Antibody-dependent enhancement (ADE) is a mechanism by which the pathogenesis of certain viral infections is enhanced in the presence of sub-neutralizing or cross-reactive non-neutralizing antiviral antibodies. In vitro modelling of ADE has attributed enhanced pathogenesis to Fcgamma receptor (FcgammaR)-mediated viral entry, rather than canonical viral receptor-mediated entry. However, the putative FcgammaR-dependent mechanisms of ADE overlap with the role of these receptors in mediating antiviral protection in various viral infections, necessitating a detailed understanding of how this diverse family of receptors functions in protection and pathogenesis. Here, we discuss the diversity of immune responses mediated upon FcgammaR engagement and review the available experimental evidence supporting the role of FcgammaRs in antiviral protection and pathogenesis through ADE. We explore FcgammaR engagement in the context of a range of different viral infections, including dengue virus and SARS-CoV, and consider ADE in the context of the ongoing SARS-CoV-2 pandemic. Twit Text FOAVip The role of IgG Fc receptors in antibody-dependent enhancement ????Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32782358 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32782358 #FOAvip English Wikipedia <ref>{{Cite pmid|32782358}}</ref> The role of IgG Fc receptors in antibody-dependent enhancement #MMPMID32782358 Bournazos S; Gupta A; Ravetch JV Nat Rev Immunol 2020[Oct]; 20 (10): 633-643 PMID32782358show ga Antibody-dependent enhancement (ADE) is a mechanism by which the pathogenesis of certain viral infections is enhanced in the presence of sub-neutralizing or cross-reactive non-neutralizing antiviral antibodies. In vitro modelling of ADE has attributed enhanced pathogenesis to Fcgamma receptor (FcgammaR)-mediated viral entry, rather than canonical viral receptor-mediated entry. However, the putative FcgammaR-dependent mechanisms of ADE overlap with the role of these receptors in mediating antiviral protection in various viral infections, necessitating a detailed understanding of how this diverse family of receptors functions in protection and pathogenesis. Here, we discuss the diversity of immune responses mediated upon FcgammaR engagement and review the available experimental evidence supporting the role of FcgammaRs in antiviral protection and pathogenesis through ADE. We explore FcgammaR engagement in the context of a range of different viral infections, including dengue virus and SARS-CoV, and consider ADE in the context of the ongoing SARS-CoV-2 pandemic. |Antibodies, Monoclonal/*administration & dosage/adverse effects/biosynthesis[MESH] |Antibodies, Neutralizing/administration & dosage/adverse effects/biosynthesis[MESH] |Antibodies, Viral/*administration & dosage/adverse effects/biosynthesis[MESH] |Antibody-Dependent Enhancement/*drug effects[MESH] |Betacoronavirus/*drug effects/immunology/pathogenicity[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/immunology/virology[MESH] |Dengue Virus/drug effects/immunology/pathogenicity[MESH] |Dengue/drug therapy/immunology/virology[MESH] |Gene Expression Regulation[MESH] |Host-Pathogen Interactions/drug effects/immunology[MESH] |Humans[MESH] |Leukocytes/*drug effects/immunology/virology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/immunology/virology[MESH] |Receptors, IgG/antagonists & inhibitors/genetics/*immunology[MESH] |SARS-CoV-2[MESH] |Severe Acute Respiratory Syndrome/drug therapy/immunology/virology[MESH] |Severe acute respiratory syndrome-related coronavirus/drug effects/immunology/pathogenicity[MESH] |Signal Transduction[MESH]The role of IgG Fc receptors in antibody-dependent enhancement (epmc).pdf DeepDyve Pubget Overpricing